Abstract
Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 μg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 μg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.
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References
Baudoin T, Ferencic Z, Ries S, Kalogjera L (1993) Evolution of neurogenic inflammation for capsaicin-induced rhinitis in the rats. Symp Otorhinol (Zagreb) 28: 35–40
Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide, and other neuropeptides. Neuroscience 24: 739–768
Kalogjera L, Baudoin T, Ferencic Z, Sikiric P (1996) Protection of cromolyn and BPC 157 on capsaicin induced rhinitis in rats. Allergologie 19: 51
Matsuda H, Kawakita K, Kiso Y, Nakano T, Kitamura Y (1989) Substance P induces granulocyte infiltration through degranulation of mast cells. J Immunol 142: 927–931
Petersson G, Malm L, Ekman R, Hakanson R (1989) Capsaicin evokes secretion of nasal fluid and depletes substance P and CGRP from the nasal mucosa in rat. Br J Pharmacol 98: 930–936
Pipkorn U (1983) Effect of topical glucocorticoid treatment on nasal mucosal mast cells in allergic rhinitis. Allergy 38: 125–129
Sikiric P, Petek M, Rueman R, Seiwerth S, Grabarevic Z, Rotkvic I, Jagic V, Mildner B, Duvnjak M, Lang N (1993) A new gastric juice peptide, BPC — an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 87: 313–327
Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Jagic V, Turkovic B, Rotkivc I, Mise S, Zoricic I, Gjurasin M, Konjevoda P, Separovic J, Ljubanovic D, Artukovic B, Bratulic M, Tisljar M, Jurina L, Buljat G, Miklic P, Marovic A (1996) The beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin and capsaicin neurotoxicity. Dig Dis Sci 41: (in press)
Veljaca M, Lech CA, Pllana R, Sanchez B, Chan K, Guglietta A (1992) BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats. J Pharmacol Exp Ther 272: 417–22
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Kalogjera, L., Ries, M., Baudoin, T. et al. Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats. Eur Arch Otorhinolaryngol 254 (Suppl 1), S9–S11 (1997). https://doi.org/10.1007/BF02439711
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DOI: https://doi.org/10.1007/BF02439711