Summary
A double-blind single-dose trial was performed on 13 patients with primary open-angle glaucoma.
Metoprolol 1%, 2%, and 4% produced a median fall in IOP of 5.6, 5.4, and 6.8 mm Hg, respectively, in the treated eye. The differences in effect between the 1%, 2%, and 4% solutions were not statistically significant. There was no significant fall in IOP in the untreated eyes. There were no significant changes in blood pressure, pulse rate, or pupilary diameter. We could not detect any local objective or subjective side effects during the single-dose study.
The clinical usefulness of metoprolol may be limited due to local toxic reactions after treatment with multiple doses. Furthermore, there is the problem of tachyphylaxis that could limit extended treatment with topical beta-adrenergic blocking drugs.
Zusammenfassung
Wir untersuchten die Wirkung einer Einzeldosis Metoprolol Augentropfen bei 13 Patienten mit Glaukom mit weitem Kammerwinkel im Doppelbindversuch. Metoprolol 1%, 2% und 4% verursachte eine mittlere Senkung des Augeninnendrucks von bzw. 5.6, 5.4 und 6.8 mm Hg im eingetropften Auge. Die Wirkung der 1%, 2% und 4% Konzentration war nicht signifikant verschieden. Bei den nicht-eingetropften Augen gab es keine signifikante Senkung des Augeninnendrucks; Blutdruck, Puls und Pupillendiameter änderten sich nicht signifikant.
Obwohl wir keine lokalen objektiven oder subjektiven Nebenwirkungen entdeckken konnten während der Einzeldosisprüfung, könnte die klinische Brauchbarkeit von Metropol beschränkt sein wegen allergischer Lokalreaktionen nach multiplen Dosen. Außerdem ist wegen Tachyphylaxis eine längere Therapie mit lokalen Beta-adrenergen Rezeptorenblokkern nicht möglich.
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References
Bietti, G.B.: Weitere Beiträge zur Deutung und Behandlung des Glaukoms. Klin. Monatsbl. Augenheilk.162, 281–295 (1972a)
Bietti, G.B.: Recent experimental, clinical, and therapeutic research on the problems of intraocular pressure and glaucoma. Am. J. Ophthalmol.73, 475–500 (1972b)
Bietti, G.B., Bucci, M.G., Pecori-Giraldi, J., Romani, E., Virno, M.: Etude sur l'action hypotonisante oculaire du propranolol et du propranolol-pilocarpine par voie locale. bull. Mem. Soc. Fr. Ophthalmol.84, 509–518 (1971)
Bietti, G.B., Bucci, M.G., Pescosolido, N.: Lokales oxprenolol bei der Behandlung verschiedener Glaukomformen. Klin. Monatsbl. Augenheilk.170, 824–830 (1977)
Bonomi, L., Steindler, P.: Effect of pindolol on intraocular pressure. Br. J. Ophthalmol.59, 301–303 (1975).
Brenkman, R.F.: Ocular hypotensive effect of atenol 4% eye drops in glaucoma. In: Symposium on medical therapy in glaucoma (ed. E.L. Greve). Doc. Ophthalmol. Proceedings Series, Vol. 12, 85–94. The Hague W. Junk 1977)
Bucci, M.G.: Topical administration of oxprenolol (beta-blocking agent) in the therapy of the glaucoma. Preliminary note. Boll. Oculist9, 235–241 (1975)
Bucci, M.G., Pecori-Giraldi, J., Missiroli, A., Virno, M.: The topical administration of propranolol in the treatment of glaucoma. Boll. Oculist.47, 51–60 (1968)
Katz, I.M., Hubbard, W.A., Getson, A.J., Gould, A.L.: Intraocular pressure decrease in normal volunteers following timolol ophthalmic solution. Invest. Ophthalmol.15, 489–492 (1976)
Krieglstein, G.K., Sold-Darseff, J., Leydhecker, W.: The intraocular pressure response of glaucomatous eyes to topically applied bupranolol. A pilot study. Albrecht von Graefes Arch. Klin. Ophthalmol.202, 81–86 (1977)
Musini, A., Fabbri, B., Bergamaschi, M., Mandelli, V., Shanks, R.G.: Comparison of the effect of propranolol, lignocaine, and other drugs on normal and raised intraocular pressure in man. Am. J. Ophthalmol.72, 773–781 (1971)
Phillips, C.I., Gore, S.M., MacDonald, M.J., Cullen, P.M.: Atenolol eye drops in glaucoma: a double masked, controlled study. Br. J. Ophthalmol.61, 349–353 (1977)
Ros, F.E., Dake, C.L., Offerhaus, L., Greve, E.L.: Atenolol 4% eyedrops and glaucoma. A double-blind short-term clinical trial of a new beta1-adrenergic blocking agent. Albrecht von Graefes Arch. Klin. Ophthalmol.205, 61–70 (1977)
Scheffé, H.: The analysis of variance. Wiley 1959
Spjøtvoll, E.: Ordering ordered parameters. Biometrika64, 327–334 (1977)
Stilma, J.S.: Use of oxprenolol eyedrops in glaucoma patients. In: Symposium on medical therapy in glaucoma (E.L. Greve, ed). Doc. Ophthalmol. Proceedings Series, Vol. 12, 95–97. The Hague: W. Junk 1977
Tieri, O., Polzella, A.: Emploi clinique et méchanisme d'action du propranololum. Ophthalmologica170, 36–42 (1975)
Vale, J., Gibbs, A.C.C., Phillips, C.I.: Topical propranolol and ocular tension in the human. Br. J. Ophthalmol.56, 770–775 (1972)
Vale, J., Phillips, C.I.: Practolol (Eraldin ℜ eye drops as an ocular hypotensive agent. Br. J. Ophthalmol.57, 210–214 (1973)
Wettrell, K., Pandolfi, M.: Effect of topical atenolol on intraocular pressure. Br. J. Ophthalmol.61, 334–338 (1977)
Zimmerman, T.J., Kaufman, H.E.: Timolol. A beta-adrenergic blocking agent for the treatment of glaucoma. Arch. Ophthalmol.95, 601–604 (1977)
Zimmerman, T.J., Kaufman, H.E.: Timolol. Dose response and duration of action. Arch. Ophthalmol.95, 605–607 (1977)
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Ros, F.E., Dake, C.L., Nagelkerke, N.J.D. et al. Metoprolol eye drops in the treatment of glaucoma a double-blind single-dose trial of a beta1-adrenergic bloking drug. Albrecht v Graefes Arch. klin. exp. Ophthal. 206, 247–254 (1978). https://doi.org/10.1007/BF02387336
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DOI: https://doi.org/10.1007/BF02387336