Summary
Stereoscopic structures of cancellous bone of human vertebral bodies were studied with a scanning electron microcope at autopsy of 2 cases of primary and 4 of secondary hyperparathyreoidism.
One principle finding are enlarged resorbing surfaces all over numerous bone trabeculae.
There is a compensatory activity of forming surfaces, which brings about mineralizing fronts and extended active osteoid seams. Active fiber osteoid predominates in cases with secondary (renal). HPT. No morphological differences can be demonstrated on bone trabeculae of dialyzed or non-dialyzed patients.
These results are in a certain contrast to SEM findings in rat parietal bone after experimental PTH administration, which showed a striking increase of resting surfaces. These short-term animal experiments, however, are not really comparable to human chronic hyperparathyreoidism.
The osteocytes of lamellar compact bone prove to be enlarged in cases of primary and secondary hyperparathyreoidism as compared to specimens of normal compact bone. The difference is slight but is statistically significant. We explain this not as periosteocytic osteolysis but as an effect of the disturbed maturation brought about by defective mineralization of the osteocyte capsules.
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Mit Unterstützung der Deutschen Forschungsgemeinschaft. Herrn Dr. med. Bernhard Karhoff zum 60. Geburtstag.
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Lindenfelser, R., Schmitt, H.P. & Haubert, P. Vergleichende rasterelektronenmikroskopische Knochenuntersuchungen bei primärem und sekundärem Hyperparathyreoidismus. Virchows Arch. Abt. A Path. Anat. 360, 141–154 (1973). https://doi.org/10.1007/BF00543225
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DOI: https://doi.org/10.1007/BF00543225