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Säurefeste Spindelkörper in der menschlichen Milz

On the etiology of spindle-shaped acid-past bodies in the human spleen

Ein Beitrag zu ihrer Ätiologie

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Summary

Spindle-shaped acid-fast bodies have been identified only in lymph nodes till now. Their nature and their origin remained unclear. We have also found these bodies in the human spleen. Their staining reactions and their correlations to age, sex, weight of spleen, and to hemosiderin deposits were examined. They have been encountered in 50% of cases of hereditary spherocytosis and in 41.7% of cases of traumatic rupture of the spleen—but only in 2.3% of all other cases of groups of various other disorders. We conclude from our results that:

  1. 1.

    The spindle-shaped acid-fast bodies are made of ceroid.

  2. 2.

    They are not causative organisms and therefore cannot be of importance in the etiology of sarcoidosis.

  3. 3.

    They derive from increased destruction of erythrocytes.

  4. 4.

    They originate due to oxidative polymerization of membrane lipids.

  5. 5.

    They may also be found in absence of any fat-metabolism disturbance.

Zusammenfassung

Säurefeste Spindelkörperchen wurden bisher nur in Lymphknoten beobachtet. Ihre Natur und ihre Ätiologie blieben unklar. Wir fanden sie auch in der menschlichen Milz. Ihr färberisches Verhalten und die Beziehungen zwischen ihrem Auftreten und dem Lebensalter, dem Geschlecht und dem Milzgewicht sowie zu bestimmten Krankheitsgruppen und Hämosiderinablagerungen wurden untersucht. Sie waren in 50% der Milzen bei hereditärer Sphärocytose und in 41,7 % der Milzen mit traumatischer Ruptur nachweisbar, dagegen nur in 2,3% aller anderen untersuchten Fälle verschiedener anderer Erkrankungen. Aus unseren Ergebnissen können wir schließen,

  1. 1.

    daß die säurefesten Spindelkörperchen aus Ceroid bestehen,

  2. 2.

    daß sie keine Erreger darstellen und somit keine Rolle für die Ätiologie der Sarkoidose spielen,

  3. 3.

    daß sie bei verstärktem Erythrocytenabbau gebildet werden können,

  4. 4.

    daß sie wahrscheinlich durch oxydative Polymerisation von Membranlipiden entstehen,

  5. 5.

    daß sie auch ohne Fettstoffwechselstörungen auftreten können.

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Authors and Affiliations

  1. Pathologisches Institut der Universität Kiel, Bundesrepublik Deutschland

    E. Schlüter, I. v. Scholz & H. J. Stutte

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  1. E. Schlüter
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  2. I. v. Scholz
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  3. H. J. Stutte
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Schlüter, E., Scholz, I.v. & Stutte, H.J. Säurefeste Spindelkörper in der menschlichen Milz. Virchows Arch. A Path. Anat. and Histol. 368, 205–212 (1975). https://doi.org/10.1007/BF00432523

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