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The hemangioendothelioma of the thyroid

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Summary

65 cases of hemangioendothelioma (HE) of the thyroid were accepted as such after control of slides of surgical or autopsy specimen or both. In a few of the more recent cases material could be examined by electron microscope and in some the search for factor VIII-related antigen (FVIIIRAG) was carried out.

The demonstration of Weibel-Palade bodies in tumour cells in two cases and the evidence of FVIIIRAG in tumour cells of at least two cases, including primary tumour and distant metastasis, finally show, that the hemangioendothelioma of the thyroid is not simply an anaplastic carcinoma with some peculiar features; at least some of these tumours are true endotheliomas.

The proposal that the term hemangioendothelioma be eliminated from the classification of thyroid tumours is therefore unfounded.

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References

  • Ackerman LV, Del Regato JA (1954) Cancer. Diagnosis, treatment, and prognosis. Mosby, St. Louis

    Google Scholar 

  • Bacher K (1953) Malignes Hämangioendotheliom der Schilddrüse unter dem Bilde einer Strumitis. Zentralbl Chir 75:1073–1075

    Google Scholar 

  • Bansky J (1973) Verlaufskontrolle einer Schilddrüsenmalignomgruppe in einem früheren Jodmangelgebiet. Diss. Zürich

  • Bezsnyak I, Besznyak G (1973) Hämangioendotheliom der Schilddrüse. Zentralbl Chir 98:132–134

    Google Scholar 

  • Blum W (1936) Tödlicher Haemothorax aus Pleurametastasen bei primärem Haemengioendotheliom der Schilddrüse. Schweiz Med Wochenschr 66:781–782

    Google Scholar 

  • Bonsetein H (1954) Le sarcome angioplastique. Tumeur vasculaire à différenciations multiples. Schweiz Z Bakteriol Pathol 17:785–788

    Google Scholar 

  • Bosse MD (1943) Hemangioendothelial sarcoma of the thyroid gland. Arch Pathol (Chicago) 36:316–318

    Google Scholar 

  • Bretscher O (1955) Seltene Ursache eines langdauernden Status febrilis (Haemengioendotheliom der Schilddrüse). Pract Oto-Rhino-Laryngol (Basel) 17:319–333

    Google Scholar 

  • Bubenhofer R, Hedinger Chr (1977) Schilddrüsenmalignome vor und nach Einführung der Jodsalzprophylaxe. Schweiz Med Wochenschr 107:7338–741

    Google Scholar 

  • Burgdorf WHC, Mukai K, Rosai J (1981) Immunohistochemical identification of factor VIII-related antigen in endothelial cells of cutaneous lesions of alleged vascular nature. Am J Clin Pathol 75:167–171

    Google Scholar 

  • Butureanu V, Marza VD, Vulpe A (1938) Sur deux cas d'hémangio-endothéliome du corps thyroide. Arch Anat Pathol (Paris) 15:691–697

    Google Scholar 

  • Cameron RG, Wang NS, Ahmed MN, Tabah EJ (1975) Small cell malignant tumours of the thyroid. Hum Pathol 6:731–740

    Google Scholar 

  • Carvos-Navarro J (1971) Elektronenmikroskopie der Hämangioblastome des Zentralnervensystems und der angioblastischen Meningiome. Acta Neuropathol (Berl) 19:184–207

    Google Scholar 

  • Chesky VE, Dreese WC, Hellwig CA (1953) Hemangioendothelioma of the thyroid. J Clin Endocrinol Metab 13:801–808

    Google Scholar 

  • Dargent M (1947) L'hémangio-endothéliome thyroidien. Membr Acad Chir (Paris) 73:429–433

    Google Scholar 

  • Depisch D, Dinstl K, Keminger K (1973) Das Schilddrüsensarkom im Endemiegebiet. Bruns Beitr Klin Chir 220:397–404

    Google Scholar 

  • Distefano G (1937) Emangio-endothelioma tiroideo sorto su un gozzo adenomatoso necrotico emorragico. Atti Mem Soc Lomb Chir (Milano) 5:637–645

    Google Scholar 

  • Egloff B (1969) The hemangioendothelioma. In: Hedinger Chr (ed). Thyroid cancer. UICC Monogr Ser, vol 12. Springer, Berlin Heidelberg New York, pp 52–59

    Google Scholar 

  • Egloff B (1977) Nicht-epitheliale Geschwülste der Schilddrüse. Verh Dtsch Ges Pathol 61:209–224

    Google Scholar 

  • Finaly R (1928) L'hémangio-endothéliome du corps thyroide. Pathologie chirurgicale, étude histologique. Diss Bern Groningen

  • Fisher ER, Gregorio R, Shoemaker R, Horvat B, Hubay Ch (1974) The derivation of so-called “giant-cell” and “spindle-cell” undifferentiated thyroidal neoplasm. Am J Clin Pathol 61:680–689

    Google Scholar 

  • Franke H, Börner W (1965) Neure Gesichtspunkte zur Diagnostik und Therapie der Struma maligna. Langenbecks Arch Klin Chir 309:309–327

    Google Scholar 

  • Frattin G (1901) Contributo alle nozione istologica degli endoteliomi dei vasi sanguini. Arch Sci Med (Torino) 25:167–185

    Google Scholar 

  • Gaal JM, Horvath E, Kovacs K (1975) Ultrastructure of two cases of anaplastic giant cell tumor of the human thyroid gland. Cancer 35:1273–1279

    Google Scholar 

  • Gerber R (1962) Un cas rare d'hémorragie digestive par métastases dans la lumiére intestinale d'un hémangio-endothéliome thyroidien. Praxis (Bern) 51:1251–1253

    Google Scholar 

  • Graham H, Daniel G (1974) Ultrastructure of an anaplastic carcinoma of the thyroid. Am J Clin Pathol 61:690–696

    Google Scholar 

  • Hahn MJ, Dawson R, Esterly JA, Joseph DJ (1973) Hemangiopericytoma. An ultrastructural study. Cancer 31:255–261

    Google Scholar 

  • Hedinger Chr, Sobin LH (1974) Histological typing of thyroid tumours. WHO International classification of tumour, Nr 11. WHO, Geneva

    Google Scholar 

  • Hedinger E (1909) Zur Lehre der Struma sarcomatosa. Frankf Z Pathol 3:487–540

    Google Scholar 

  • Hopfner C, Dufour M, Pluot M, Caulet T (1972) Hémangio-endothéliosarcome splénique avec érythrophagocytose et angiopathie thrombotique. Etude morphologique, optique et ultrastructurale. Virchows Arch [Pathol Anat] 356:66–75

    Google Scholar 

  • Hoyer LW, De Los Santos RP, Hoyer JR (1973) Antihemophilic factor antigen. Localization in endothelial cells by immunofluorescent microscopy. J Clin Invest 52:2737–2744

    Google Scholar 

  • Jaffe EA, Nachman RL, Becker CG, Minick RC (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52:2745–2756

    Google Scholar 

  • Jao W, Gould VE (1975) Ultrastructure of anaplastic (spindle and giant cell) carcinoma of the thyroid. Cancer 35:1280–1292

    Google Scholar 

  • Johannessen JV, Gould VE, Jao W (1978) The fine structure of human thyroid cancer. Hum Pathol 9:385–400

    Google Scholar 

  • Kind HP (1966) Die Häufigkeit der Struma maligna im Sektions- und Operationsgut des Pathologischen Instituts der Universität Zürich von 1900 bis Mitte 1964. Schweiz Med Wochenschr 96:560–568

    Google Scholar 

  • Klinck GH (1969) Hemangioendothelioma and sarcoma of the thyroid. In: Hedinger Chr (ed). Thyroid cancer. UICC Monogr Ser, vo. 12. Springer, Berlin Heidelberg New York, pp 60–64

    Google Scholar 

  • Klinck GH, Oertel JE, Winship Th (1970) Ultrastructure of normal human thyroid. Lab Invest 22:2–22

    Google Scholar 

  • Krisch K, Holzner JH, Kokoschka R, Jakesz R, Niederle B, Roka R (1980) Hemangioendothelioma of the thyroid gland. True endothelioma or anaplastic carcinoma? Pathol Res Pract 170:230–242

    Google Scholar 

  • Lessen H Van, Azzola-Van Lessen U, Bechtelsheimer H (1969) Klinik und Morphologie der Struma maligna. Bruns Beitr Klin Chir 217:108–123

    Google Scholar 

  • Limacher F (1898) Über Blutgefäßendotheliome der Struma mit einem Anhang über Knochenmetastasen bei Struma maligna. In: Virchow R (ed). Beiträge zur Geschwulstlehre. Arch Pathol Anat Physiol Klin Med (Suppl) 151:113–150

    Google Scholar 

  • Martin JF, Dargent M, Guinet P (1947) L'hémangio-endothéliome du corps thyroide. D'après cinq observations personelles. Ann Anat Pathol (Paris) 17:219–235

    Google Scholar 

  • Matti H (1935) Über gingivale Metastasen eines Haemangioendothelioms der Schilddrüse. Schweiz Med Wochenschr 65:59–61

    Google Scholar 

  • Meissner WA, Warren S (1969) Tumors of the thyroid gland. Atlas of tumor pathology. Sec Ser Fasc 4. Armed Forces Institute of Pathology, Washington

    Google Scholar 

  • Mollwo S (1947) Über die Histogenese des Haemangioendothelioms und Sarkoms der Schilddrüse. Schweiz Z Pathol Bakteriol 10:80–123

    Google Scholar 

  • Mukai K, Rosai J, Burgdorf WC (1980) Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxydase method. Am J Surg Pathol 4:273–276

    Google Scholar 

  • Murad TM, Van Haam E, Murray MSN (1968) Ultrastructure of a hemangiopericytoma and a glomus tumour. Cancer 22:1239–1249

    Google Scholar 

  • Neracher H, Hedinger Chr (1975) Klassifizierung der Schilddrüsenmalignome nach der Nomenklatur der WHO 1974. Histologische Nachkontrolle von 327 bösartigen Schilddrüsentumoren. Schweiz Med Wochenschr 105:1000–1006 & 1052–1056

    Google Scholar 

  • Paullada JJ, Lisci-Garmilla A, Gonzales-Angulo A, Jurado-Mendoza J, Quijano-Narezo M, Gomez-Peralta L, Doria-Medina M (1968) Hemangiopericytoma associated with hypoglycemia. Metabolic and electron microscopic studies of a case. Am J Med 44:990–999

    Google Scholar 

  • Pollard SM, Millward-Sadler GH (1974) Malignant haemangioendothelioma involving the liver. J Clin Pathol 27:214–221

    Google Scholar 

  • Quervain F De (1941) Die Struma maligna. Neue Deutsche Chirurgie, Band 64. Enke, Stuttgart

    Google Scholar 

  • Ramsey HJ (1966) Fine structure of hemangiopericytoma and hemangio-endothelioma. Cancer 19:2005–2018

    Google Scholar 

  • Rand JH, Sussman II, Gordon RE, Chu SV, Solomon V (1980) Localization of factor VIII-related antigen in human vascular-subendothelium. Blood 55:752–756

    Google Scholar 

  • Rausch GR (1935/36) Haemangioendotheliome der Schilddrüse. Diss Bern

  • Rilke F, Scomazzoni G (1958) L'emangioendothelioma della tiroide. Presentazione di un caso. Arch Ital Anat Istol Pathol 32:122–146

    Google Scholar 

  • Saito R, Sharma K (1976) Fine structure of a diffuse undifferentiated small-cell carcinoma of the thyroid. Am J Clin Pathol 65:623–630

    Google Scholar 

  • Sapinski H (1941) Das Hämangioendotheliom der Schilddrüse als Ursache eines Hämatothorax. Dtsch Med Wochenschr 67:93–96

    Google Scholar 

  • Saxén E (1951) Sarcoma and sarcomatoid carcinoma of the thyroid. Incidence in Finland. Ann Chir Gynaec Fenn 40:34–50

    Google Scholar 

  • Sehested M, Hou-Jensen K (1981) Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch [Pathol Anat] 391:217–225

    Google Scholar 

  • Sellers EA, Schönbaum E (1962) Blood vessels of experimental thyroid tumours. Acta Endocrinol (Copenh) 40:51–59

    Google Scholar 

  • Silverberg SG, Vidone RA (1966) Carcinoma of the thyroid in surgical and postmortem material. Analysis of 300 cases at autopsy and literature review. Ann Surg 164:291–299

    Google Scholar 

  • Simon MA (1939) Hemangioendothelial sarcoma of the thyroid with extension into the trachea and with massive hemoptysis. Arch Pathol (Chicago) 27:571–579

    Google Scholar 

  • Steiner GC, Dorfman HD (1972) Ultrastructure of hemangioendothelial sarcoma of bone. Cancer 29:122–135

    Google Scholar 

  • Stühlinger H (1940) Haemangioendothelioma sarcomatoides der Schilddrüse. Frankf Z Pathol 54:473–493

    Google Scholar 

  • Thalmann A (1954) Die Häufigkeit der Struma maligna am Berner Pathologischen Institut von 1910–1950 und ihre Beziehung zur Jodprophylaxe des endemischen Kropfes. Schweiz Med Wochenschr 84:473–478

    Google Scholar 

  • Thorgeirsson G, Robertson AL jr (1978) The vascular endothelium-pathobiologic significance. Am J Pathol 93:803–848

    Google Scholar 

  • Valenta LJ, Michel-Béchet M (1977) Ultrastructure and biochemistry of thyroid carcinoma. Cancer 40:284–300

    Google Scholar 

  • Veronesi U, Cascinelli N, Preda F (1969) I tumori maligni mesenchímali della tiroide. Tumori 55:417–422

    Google Scholar 

  • Waldo ED, Vuletin JC, Kaye GI (1977) The ultrastructure of vascular tumors: additional observations and a review of the literature. Pathol Annu 12 (Pt2). Appleton, New York, pp 279–308

    Google Scholar 

  • Ward R (1935) Malignant goitre. A survey of geographical types. West J Surg 43:494–504

    Google Scholar 

  • Warren S, Meissner WA (1953) Tumors of the thyroid gland. Atlas of Tumor Pathology, Sect 4, Fasc 14. Armed Forces Institute of Pathology, Washington

    Google Scholar 

  • Wegelin C (1926) Das Haemangioendotheliom der Schilddrüse. In: Henke F, Lubarsch O (eds). Handbuch der speziellen pathologischen Anatomie und Histologie, Band 8. Springer, Berlin, pp 297–302

    Google Scholar 

  • Weibel ER, Palade GE (1964) New cytoplasmic components in arterial endothelioma. J Cell Biol 23:101–112

    Google Scholar 

  • Welch JW, Hellwig CA (1963) Multiple malignant tumors of the thyroid. J Int Coll Surg (Edinburgh) 40:492–497

    Google Scholar 

  • Weldon-Linne CM, Victor TA, Christ ML (1981) Immunohistochemical identification of factor VIII-related antigen in the intravascular bronchioalveolar tumor of the lung. Arch Pathol Lab Med 105:628–629

    Google Scholar 

  • Willis RA (1953) Pathology of tumours, 2 ed. Butterworths, London

    Google Scholar 

  • Winnen P (1920) Ein malignes Hämangioendotheliom der Schilddrüse. Frankf Z Pathol 23:405–418

    Google Scholar 

  • Woolner LB, Beahrs OH, Black BM, McConahey WM, Keating FR jr (1968) Thyroid carcinoma: general considerations and follow-up data on 1181 cases. In: Young St, Inman DR (eds) Thyroid neoplasia. Academic Press, London New York, pp 51–79

    Google Scholar 

  • Wülfling HW (1934) Beitrag zur Frage der Struma maligna. Z Krebsforsch 41:74–86

    Google Scholar 

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  1. Pathologisches Institut, Kantonsspital, Postfach, CH-8401, Winterthur, Switzerland

    B. Egloff

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Egloff, B. The hemangioendothelioma of the thyroid. Vichows Archiv A Pathol Anat 400, 119–142 (1983). https://doi.org/10.1007/BF00585495

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