Summary
Fibro-osteo-cemental lesions of the jaw bones are a heterogeneous group of diseases which present problems in classification. Psammous desmo-osteoblastoma is one of four newly proposed entities (Makek 1983) and has until now been characterized by its light microscopic, clinical and radiological features. On electron microscopy this tumour exhibits fibroblastic (preosteoblastic), osteoblastic and osteocytic cells and a globular mineralization unlike the mineralization of the psammoma bodies. Immunohistological investigations with anti-osteonectin, a bone specific protein linking mineral to collagen, showed positive intracellular staining in all tumour cells and extracellular staining in the osteoid. The psammoma bodies were, however, not stained. These results confirm the view of the osteogenic histogenesis of psammous desmo-osteoblastoma, with an osteogenic differentiation of the tumour cells, bone formation and association of psammoma bodies which are not of bone origin. This combination of findings supports the view that psammous desmo-osteoblastoma represents a new and distinct entity occuring in desmal preformed cranio-facial bones which should be incorporated in a revised WHO-classification.
Similar content being viewed by others
References
Aoba TH, Yoshioka C, Ogawa Y, Yagi T (1978) A study of the mineral phase of cementifying fibroma. J Oral Pathol 7:156–161
Bhaskar SN (1986) Synopsis of oral pathology Mosby St Louis, Toronto, London, p 318
Burkhardt A (1985) Das Ektomesenchym - seine Bedeutung für die Diagnostik. Verh Deutsch Ges Pathol 9:607
Burkhardt A (1986) Klassifizierung von fibromatösen Kieferläsionen mit Hartgewebsbildung - neue Aspekte. Dtsch Z Mund Kiefer Gesichts Chir 10:225–230
Donath K (1986a) Literaturüberblick zur fibro-ossären Kieferläsion. Dtsch Z Mund Kiefer Gesichts Chir 10:208
Donath K (1986b) Ultrastrukturpathologie der fibro-ossären Kieferläsionen. Dtsch Z Mund Kiefer Gesichts Chir 10:218–224
Hirohata K, Morimoto K (1971) Ultrastructure of bone and joint disease. Excerpta Medica Amsterdam
Hoppe W (1986) Zur Klinik der sogenannten “Fibro-zemento-ossären Kieferläsionen”. Dtsch Z Mund Kiefer Gesichts Chir 10:209–211
Jundt G, Schulz A, Berghäuser KH, Termine JD (1986) Osteonectin is an immunocytochemical marker of osteosarcoma cells. Cancer Res Clin Oncol 111 (suppl):150
Kepes JJ (1982) Meningeomas - biology, pathology and differential diagnosis. Masson, New York Paris Barcelona Milan Mexico City Rio de Janeiro, p 150
Knese KH (1979) Stützgewebe und Skelettsystem Handbuch der mikroskopischen Anatomie des Menschen II/5. Springer, Berlin Heidelberg New York, p 513
Makek M (1983) Clinical pathology of fibro-osteo-cemental lesions in the cranio-facial and jaw bones. A new approach to differential diagnosis. S Karger, Basel New York
Makek M (1986) Klinische Pathologie und Differentialdiagnose der fibro-ossären Läsionen im Kiefer-Gesichtsbereich -neue Aspekte. Dtsch Z Mund Kiefer Gesichts Chir 10:212–217
Makek M (1987) So called “fibro-osseous Lesions” of tumorous origin. Biology confronts terminology. J Max-Fac Surg
Moss TH (1986) Tumours of the nervous system - an ultrastructural atlas. Springer, London Berlin Heidelberg New York Paris Tokyo, p 85
Pindborg JJ, Kramer IRH (1971) Histological typing of odontogenic tumours, jaw cysts, and allied lesions. World Health Organization, Geneva
Polak JM, van Noorden S (1983) Immunocytochemistry. Wright PSG, Bristol London Boston
Robinson HBG, Miller AS (1983) Color atlas of oral pathology. Lipincott, Philadelphia Toronto
Roessner A (1984) Zur Zyto- und Histogenese der malignen und semimalignen Knochentumoren. Fischer, Stuttgart New York
Romberg RW, Werness PG, Lollar P, Riggs BL, Mann KG (1985) Isolation and characterization of native adult osteonectin. J Biol Chem 260:2728–2736
Sailer HF, Makek M (1986) Therapeutisches Konzept beim Desmoosteoblastom und Periodontom mit Beschreibung einer neuen Form der Oberkiefer-Sofortrekonstruktion. In: EW Steinhäuser (ed) Knochentumoren und Systemerkrankungen im Kiefer-Gesichts-Bereich; Fortschr. Kiefer- und Gesichtschir. Bd. XXXI. Thieme, Stuttgart New York, pp 128–131
Schroeder HE (1982) Orale Strukturbiologie Thieme, Stuttgart New York
Schulz A (1980) Ultrastrukturpathologie der Knochentumoren Fischer, Stuttgart New York
Schulz A, Jundt G, Berghäuser KH, Termine JD (1985) Osteonectin - ein immuncytochemischer Marker von Knochentumorzellen Verh Dtsch Ges Pathol 69:604
Smith RM, Turner JE, Robbins ML (1981) Atlas of oral pathology Mosby St. Louis, Toronto London
Steiner GC (1977) Ultrastructure of osteoblastoma Cancer 39:2127–2136
Störkel S, Stender E, Wagner W, v. Domarus H (1986) Gibt es ein psammöses Desmo-Osteoblastom im knöchernen Gesichtsschädel? Verh Dtsch Ges Pathol 70:443
Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (1981) Osteonectin, a bone-specific protein linking mineral to collagen. Cell 26:99–105
Waldron CHA, Giansanti JS (1973) Benign fibro-osseous lesions of the jaws: a clinical - radiologic - histologic review of sixty-five cases. Part II Benign fibro-osseous lesions of periodontal ligament origin. Oral Surg 35:340–350
Waldron CHA (1985) Fibro-osseous lesions of the jaws. J Oral Maxillofac Surg 43:249–262
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Störkel, S., Wagner, W. & Makek, M.S. Psammous desmo-osteoblastoma. Vichows Archiv A Pathol Anat 411, 561–568 (1987). https://doi.org/10.1007/BF00713287
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00713287