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Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders

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Summary

One hundred and seventy bone marrow biopsies from patients with chronic myeloproliferative disorders (CMPDs) were evaluated for the presence of lymphoid nodules (LNs) and were immunostained using a panel of monoclonal antibodies (UCHL1, 4KB5 and L26) recognizing different lymphocyte antigens. LNs were found in 35% of cases of idiopathic thrombocythaemia, 24.6% of myelofibrosis/osteomyelosclerosis, 18.2% of polycythaemia vera, 12.1% of chronic myeloid leukaemia and 19.2% of borderline cases. Varying degrees of immunohistochemical positivity for the three antibodies tested were found. LNs were always made up of variable proportions of both T-and B-lymphocytes with a prevalence of T-cells. This latter observation suggests that bone marrow LNs in CMPDs could be an expression of reactivity.

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Authors and Affiliations

  1. Institute of Pathological Anatomy, University of Palermo, Palermo, Italy

    Vito Franco, Ada Maria Florena, Federico Aragona & Giuseppe Campesi

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  1. Vito Franco
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  2. Ada Maria Florena
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  3. Federico Aragona
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  4. Giuseppe Campesi
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Franco, V., Florena, A.M., Aragona, F. et al. Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders. Vichows Archiv A Pathol Anat 419, 261–266 (1991). https://doi.org/10.1007/BF01606516

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  • DOI: https://doi.org/10.1007/BF01606516

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