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Diffuse axonal injury: Windows for therapeutic intervention allowed by its pathobiology

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References

  • Adams JH, Mitchell DE, Graham DI, Doyle D (1977) Diffuse brain damage of immediate impact type: its relationship to “primary brain-stem damage” in head injury. Brain 100:489–502

    Google Scholar 

  • Adams JH, Graham DI, Murray LS, Scott G (1982) Diffuse axonal injury due to nonmissile head injury in humans: an analysis of 45 cases. Ann Neurol 12:557–563

    Google Scholar 

  • Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, McLellan DR (1989) Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology 15:49–59

    Google Scholar 

  • Alves WM, Jane JA (1985) Mild brain injury: damage and out-come. In: Becker DP, Povlishock JT (eds) Central nervous system trauma status report. National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, pp 255–270

  • Arends MJ, Morris RG, Wyllie AH (1990) Apoptosis: the role of the endonuclease. Am J Pathol 136:593–608

    Google Scholar 

  • Bracken MB, Shepard MJ, Collins WF, Holford TR, Young W, Baskin DS, Eisenberg HM, Flamm E, Leo-Sumers L, Maroon J, Marshall LF, Perot PL, Piepmeier J, Sonntag VKH, Wagner FC, Wilberger JE, Winn HR (1990) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. N Engl J Med 322:1405–1411

    Google Scholar 

  • Campbell BJ (1992) Reducing traffic injury: size of the problem and lack of research resources. World J Surg 16:384–388

    Google Scholar 

  • Crompton R (1985) Closed head injury: its pathology and legal medicine. Edward Arnold, London

    Google Scholar 

  • Erb DE, Povlishock JT (1988) Axonal damage in severe traumatic brain injury: an experimental study in the cat. Acta Neuropathol (Berl) 76:347–358

    Google Scholar 

  • Ferguson IA, Johnson EM Jr (1991) Fibroblast growth factor receptor-bearing neurons in the CNS: identification by receptor-mediated retrograde transport. J Comp Neurol 313:693–706

    Google Scholar 

  • Ferguson IA, Schweitzer JB, Bartlett PF, Johnson EM Jr (1991) Receptor-mediated retrograde transport in CNS neurons after intraventricular administration of NGF and growth factors. J Comp Neurol 313:680–692

    Google Scholar 

  • Gallyas F, Zoltay G (1992) An immediate light microscopic response of neuronal somata, dendrites, and axons to non-contusing concussive head injury in the rat. Acta Neuropathol (Berl) 83:386–393

    Google Scholar 

  • Gallyas F, Zoltay G, Balas I (1992) An immediate light microscopic response of neuronal somata, dendrites and axons to contusing head injury in the rat. Acta Neuropathol (Berl) 83:394–401

    Google Scholar 

  • Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493–501

    Google Scholar 

  • Gennarelli TA, Spielman GM, Langfitt TW, Gildenberg PL, Harrington T, Jane JA, Marshall LF, Miller JD, Pitts LH (1982) Influence of the type of intracranial lesion on the outcome from severe head injury. J Neurosurg 56:26–32

    Google Scholar 

  • Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT (1993) The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol 52:143–152

    Google Scholar 

  • Graham DI, McLellan JH, Adams JH, Doyle D, Kerr A, Murray LS (1983) The neuropathology of the vegetative state and severe disability after non-missile head injury. Acta Neurochirurgica [Suppl] 32:65–67

    Google Scholar 

  • Hall ED (1992) The neuroprotective pharmacology of methylprednisolone. J Neurosurg 76:13–22

    Google Scholar 

  • Hatziandreu E, Graham JD, Stoto MA (1988) AIDS and biomedical research funding: comparative analysis. Rev Infect Dis 10:159–167

    Google Scholar 

  • Hefti F (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections. J Neurosci 6:2155–2162

    Google Scholar 

  • Kraus JF (1993) Epidemiology of head injury. In: Cooper PR (ed) Head injury. Williams and Wilkins, Baltimore pp 1–25

    Google Scholar 

  • Kromer LF (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science 235:214–216

    Google Scholar 

  • Martin DP, Schmidt RE, DiStefano PS, Lowry OH, Carter JG, Johnson EM Jr (1988) Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J Cell Biol 106:829–844

    Google Scholar 

  • Maxwell WL, Graham AI, Adams JH, Gennarelli TA, Tipperman R, Sturatis M (1991) Focal axonal injury: the early axonal response to stretch. J Neurocytol 20:157–164

    Google Scholar 

  • Ommaya AK, Rockoff SD, Baldwin M (1964) Experimental concussion: a first report. J Neurosurg 21:249–264

    Google Scholar 

  • Oppenheim RW, Prevette D, Tytell M, Homma S (1990) Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev Biol 138:104–113

    Google Scholar 

  • Oppenheimer DR (1968) Microscopic lesions of the brain following head injury. J Neurol Neurosurg Psychiatry 31:299–306

    Google Scholar 

  • Peerless SJ, Rewcastle NB (1967) Shear injuries of the brain. Can Med Assoc J 96:577–582

    Google Scholar 

  • Pilz P (1983) Axonal injury in head injury. Acta Neurochirurgica 32:119–123

    Google Scholar 

  • Povlishock JT (1992) Traumatically induced axonal injury: pathogenesis and pathobiological implications. Brain Pathol 2:1–12

    Google Scholar 

  • Rinder L, Olsson Y (1968) Studies on vascular permeability changes in experimental brain concussion I. Distribution of circulating fluorescent indicators in brain and cervical cord after sudden mechanical loading of the brain. Acta Neuropathol (Berl) 11:183–200

    Google Scholar 

  • Strich SJ (1956) Diffuse degeneration of the cerebral white matter in severe dementia following head injury. J Neurol Neurosurg Psychiatry 19:163–185

    Google Scholar 

  • Wyllie AH (1987) Cell death. Int Rev Cytol 17 [Suppl]: 755–785

    Google Scholar 

  • Yaghmai A, Povlishock J (1992) Traumatically induced reactive change as visualized through the use of monoclonal antibodies targeted to neurofilament subunits. J Neuropathol Exp Neurol 51:158–176

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Division of Neuropathology, University of Tennessee, Memphis, Tennessee, USA

    John B. Schweitzer & F. Curtis Dohan Jr.

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  1. John B. Schweitzer
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  2. F. Curtis Dohan Jr.
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Schweitzer, J.B., Dohan, F.C. Diffuse axonal injury: Windows for therapeutic intervention allowed by its pathobiology. Vichows Archiv A Pathol Anat 423, 153–156 (1993). https://doi.org/10.1007/BF01614764

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