Abstract
Extranodal lymphomas of the thyroid (n=19), kidney (n=15) and testis (n=30) were investigated histologically and immunohistochemically for follicular dendritic cell pattern using the monoclonal antibody Ki-FDC1P. This recognizes follicular dendritic cells in paraffin sections. Follicular dendritic cells were most predominant in lymphomas of the thyroid. These thyroid lymphomas showed the morphological features of mucosa-associated lymphoid tissue (MALT) type lymphomas in 18 of 19 cases and were classified as high-grade malignant lymphoma of MALT type with evidence of a low-grade malignant component (n=18). Ten of these cases contained destroyed reactive follicles of follicular dendritic cells. In 6 of these 10 cases follicular dendritic cells occurred in a pattern of tumour-associated abortive follicle type. The remaining lymphoma of the thyroid was an immunoblastic lymphoma of B-cell type showing no detectable follicular dendritic cells. In extranodal lymphomas of non-MALT type follicular dendritic cells occurred in only two cases where immunocytoma involved the kidney. Malignant lymphomas of the kidney (chronic lymphocytic leukaemia,n=2; immunocytoma,n=4; centroblastic lymphoma,n=9) and of the testis (immunocytoma,n=2; centroblastic lymphoma,n=27; immunoblastic lymphoma of B-cell type,n=1) revealed no characteristics of MALT type lymphoma, cytologically or with respect to follicular dendritic cells. Classical lymphoepithelial lesions formed by centrocyte-like cells, a hallmark of MALT, occurred exclusively in thyroid lymphomas of MALT type. Although occurrence of classical lymphoepithelial lesions formed by centrocyte-like cells was limited to thyroid lymphomas of MALT type, a growth pattern of lymphoid blasts, with formation of lesions mimicking lymphoepithelial lesions superficially, was found in 6 of 27 testicular centroblastic lymphomas. Follicular dendritic cells in non-Hodgkin's lymphomas of MALT type show distinct follicular patterns not found in other extranodal lymphomas such as those found in the kidney and testis.
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Alavaikko MJ, Hansmann M-L, Nebendahl C, Parwaresch MR, Lennert K (1991) Follicular dendritic cells in Hodgkin's disease. Am J Clin Pathol 95:194–200
Anscombe AM, Wright DH (1985) Primary malignant lymphoma of the thyroid — a tumour of mucosa-associated lymphoid tissue. Histopathology 5:81–97
Aozasa K (1990) Hashimoto's thyroiditis as a risk factor of thyroid lymphoma. Acta Pathol Jpn 40:459–468
Burke JS, Butler JJ, Fuller LM (1977) Malignant lymphomas of the thyroid. Cancer 39:1587–1602
Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KAF, Stein H, Mason DY (1984) Immuno-enzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP) complexes. J Histochem Cytochem 32:219–229
Deuskar C, Martin LFW, Leung W (1987) Renal lymphoma: an unusual example. J Can Assoc Radiol 38:133–135
Doll DC, Weiss RB (1986) Malignant lymphoma of the testis. Am J Med 81:515–524
Falconieri G, Melato M (1987) Malignant lymphomas presenting as an isolated renal mass. Histopathology 12:217–219
Guettier C, Gatter KC, Heryet A, Mason DY (1986) Dendritic reticulum cells in reactive lymph nodes and tonsils: an immunohistological study. Histopathology 10:15–24
Hansmann ML, Wacker HH (1990) Immunoelectron-microscopic investigations of lymph nodes. Curr Top Pathol 84:265–280
Hyjek E, Isaacson PG (1988) Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis. Hum Pathol 19:1315–1326
Imai Y, Matsuda M, Maeda K, Yamakawa M, Dobashi M, Satoh H, Terashima T (1991) Dendritic cells in lymphoid tissues — their morphology, antigenic profiles and functions. In: Imai Y, et al (eds) Dendritic cells in lymphoid tissues. Elsevier, Amsterdam, pp 3–13
Isaacson PG (1990) Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology 16:617–619
Isaacson PG, Spencer J (1987) Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 11:445–462
Isaacson PG, Spencer J, Wright DH (1988) Classifying primary gut lymphomas. Lancet II:1148–1149
Isaacson PG, Androulakis-Papachristou A, Diss TC, Pan L, Wright DH (1992) Follicular colonization in thyroid lymphoma. Am J Pathol 41:43–52
Klaus GGB, Humphrey JH, Kunkl A, Dongworth DW (1980) The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol Rev 53:3–28
Lennert K, Feller AC (1992) Histopathology of non-Hodgkin's lymphomas. Springer, Berlin Heidelberg New York, pp 111–114
Leoncini L, Minacci C, Rivano MT, Cantore M, Pileri S (1988) Primary multilobated B cell lymphoma of the kidney. Appl Pathol 6:276–280
Martinez-Maldonado M, De Arellano GAR (1966) Renal involvement in malignant lymphomas. J Urol 95:485–488
Matias-Guiu X, Esquius J (1991) Lymphoepithelial lesion in the thyroid — a non-specific histological finding. Pathol Res Pract 187:296–300
Moore I, Wright DH (1984) Primary gastric lymphoma — a tumour of mucosa-associated lymphoid tissue. Histopathology 8:1025–1039
Nonomura N, Aozasa K, Ueda T, Okuyama A, Matsuda M, Hida S, Yoshida O, Kobashi Y, Shima N, Yamabe H (1989) Malignant lymphoma of the testis. J Urol 141:1368–1371
Osborne BM, Brenner M, Weitzner S, Butler JJ (1987) Malignant lymphoma presenting as a renal mass. Am J Surg Pathol 11:375–382
Paladugu RR, Bearman RM, Rappaport H (1980) Malignant lymphoma with primary manifestation in the gonad. Cancer 45:561–571
Richards MA, Mootoosamy I, Reznek RH, Webb JAW, Lister TA (1990) Renal involvement in patients with non-Hodgkin's lymphoma. Hematol Oncol 8:105–110
Scoazec J-Y, Berger F, Magaud J-P, Brochier J, Coiffier B, Bryon P-A (1989) The dendritic reticulum cell pattern in B cell lymphomas of the small cleaved, mixed, and large cell types. Hum Pathol 20:124–131
Stansfeld AG, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewska O, Noel H, Rilke F, Sundstrom C, Van Unnik JAM, Wright DH (1988) Updated Kiel classification for lymphomas. Lancet 1:292–293, 603
Sussman EB, Hajdu SI, Lieberman PH, Whitmore WF (1977) Malignant lymphoma of the testis. J Urol 118:1004–1007
Tabrizchi H, Hansmann M-L, Parwaresch MR, Lennert K (1990) Distribution pattern of follicular dendritic cells in low grade B-cell lymphomas of the gastrointestinal tract immunostained by Ki-FDClp: a new paraffin-resistant monoclonal antibody. Mod Pathol 3:470–478
Tsunoda R, Nakayama M, Heinen E, Miyake K, Suzuki K, Sugai N, Kojima M (1992) Emperipolesis of lymphoid cells by human follicular dendritic cells in vitro. Virchows Arch [B] 62:69–78
Turner RR, Colby TV, MacKintosh FR (1981) Testicular lymphomas. Cancer 48:2095–2102
Van den Oord JJ, De Wolf-Peeters C, Desmet VJ (1985) Immunohistochemical analysis of progressively transformed follicular centers. Am J Clin Pathol 83:560–564
Wilkins BS, Williamson JMS, O'Brien CJ (1989) Morphological and immunohistological study of testicular lymphomas. Histopathology 15:147–156
Woolner LB, McConahey WM, Beahrs OH, Black SM (1966) Primary malignant lymphoma of the thyroid. Review of forty-six cases. Am J Surg 111:502–523
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Fellbaum, C., Sträter, J. & Hansmann, M.L. Follicular dendritic cells in extranodal non-Hodgkin lymphomas of MALT and non-MALT type. Vichows Archiv A Pathol Anat 423, 335–341 (1993). https://doi.org/10.1007/BF01607145
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DOI: https://doi.org/10.1007/BF01607145