Abstract
Two siblings of consanguineous Arab parents were found to have cystic fibrosis and gastritis associated withHelicobacter pylori, folate deficiency megaloblastic anaemia, subnormal mentality and minor anomalies. The association ofH. pylori and megaloblastic anaemia has not been described in patients with cystic fibrosis.H. pylori infection and gastritis is probably more common in patients with cystic fibrosis than appreciated. We believe that the constellation of features in the two sibs represent a possible new autosomal recessive cystic fibrosis-like syndrome.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- CF:
-
cystic fibrosis
- DHFR:
-
dihydrofolate reductase
- Hb:
-
haemoglobin
- H. pylori :
-
Helicobacter pylori
- IQ:
-
intelligence quotient
- MCH:
-
mean corpuscular haemoglobin
- MCV:
-
mean corpuscular volume
References
Buchwald M, Zsiga M, Markiewicz D, Plavsic N, Kennedy D, Zengerling S, Willard HF, Tsipouras P, Schmiegelow K, Schwartz M, Eiberg H, Mohr J, Barker D, Donis-Keller H, Tsui LC (1986) Linkage of cystic fibrosis to the pro-alphy 2 (I) Collagen gene, COLLIAZ on Chromosome 7. Cytogenet Cell Genet 41:234–239
Burnett RA, Forrest JAH, Girdwood RWA, Fricker CR (1984) Letter to the editor. Lancet I:1349
Czinn SJ, Dahms BB, Jacobs GH, Kaplan B, Rothstein FC (1986) Campylobacter like organisms in association with symptomatic gastritis in children. J Pediatr 109:80–83
Funanage VL, Myoda TT, Moses PA, Cowell HR (1984) Assignment of the human dihydrogolate reductase gene to q 11-1 22 region of chromosome S. Melec Cell Biol 4:2010–2016
Hazell SL, Lee A, Brady L, Hennessy W (1986) Campylobacter pyloridis and gastritis; association with intracellular space and adaptation to an environment of mucous as important factor in colonization of the gastric epithelium. J Infec Dis 153: 658–663
Hill ID, Sinclair-Smith C, Latovica AJ, Bowie MD, EMNS M (1987) Transient protein losing enteropathy associated with acute gastritis and campylobacter pylori. Arch Dis Child 62: 1215–1219
Hornick RB (1987) Peptic Ulcer disease: a bacterial infection? N Engl J Med 316:1598–1600
Jones KL (1988) Smith's recognizable patterns of human malformations, 4th edn. W.B. Saunders, Philadelphia
Jones DM, Lessells AM, Eldridge J (1984) Campylobacter-like organisms on the gastric mucosa: culture, histological and serological studies. J Clin Pathol 37:1002–1006
Kamal MF, Nazer H (1984) Cystic fibrosis in Jordan, a pilot study. Ann Trop Paediatr 4:243–246
Katznelson D (1982) Cystic fibrosis in the Middle East. Lancet I:12
Khalil M, Tanios A, Moghazy M, Mahmoud S, El-Lozy M (1974) Serum and red cell folates, and serum B12 in protein calorie malnutrition. Arch Dis Child 49:736
Kollberg H (1966) Cystic fibrosis in Kuwait. J Trop Paediatr 32:293–294
Kollberg H, Nazer H, Alagapan V, Bulizherkov V (1986) Cystic fibrosis in Arabic and Indian population: proceeding of IPA meeting and A.A.P. held in Honolulu, July 1986
Mahony MJ, Wyatt JI, Littlewood JM (1988) Campylobacter pylori gastritis. Arch Dis Child 63:654–666
McKusick VA (1988) Mendelian inheritance in man. Catalogs of autosomal dominant, autosomal recessive, and X-linked phenotypes, 8th edn. John Hopkins, Baltimore
Nazer H (1986) Cystic fibrosis in Jordan, incidence and prevalence. Trans R Soc Trop Med Hyg 80:348
Rathbone BJ, Wyattji JI, Heatley RV (1986)Campylobacter pyloridis: a new factor in peptic ulcer disease. Gut 27:635–641
Warren JR, Marshall BJ (1983) Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet I:1273–1275
WHO/ICF (M) (1985) A meeting. Cystic fibrosis. Bull WHO 63:1–10
Zueizer WW, Ogden FN (1946) Megaloblastic anaemia of infancy. Am J Dis Child 71:211
Zuelzer WW, Rutsky J (1950) Megaloblastic anaemia of infancy. Adv Pediatr 6:243
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lubani, M.M., Al-Saleh, Q.A., Teebi, A.S. et al. Cystic fibrosis and Helicobacter pylori gastritis, megaloblastic anaemia, subnormal mentality and minor anomalies in two siblings: a new syndrome?. Eur J Pediatr 150, 253–255 (1991). https://doi.org/10.1007/BF01955524
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01955524