Summary
Light- and electron-microscopic investigations were performed in a case of cystic soap-bubble-like expansion of the shaft region of the second metatarsal bone. Morphologically, strongly cellular tissue with a closely packed net of osteoid trabeculae containing osteoblasts and a whorl-shaped spindle cell stroma with fibroblasts, fibrocytes, and irregularly scattered multinucleated giant cells of the osteoclast type were observed. After clinical and morphological exclusion of osteosarcoma, enchondroma, non-ossifying fibroma, osteoblastoma, osteoclastoma, and bone cysts the final diagnosis was giant-cell reaction of small tubular bone with unusual marked osteoid formation. As recurrences are possible, block resection appears more appropriate than curettage.
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Helpap, B., Totovic, V. & Bechtelsheimer, H. Giant-cell reaction in the small tubular bones. J Cancer Res Clin Oncol 101, 219–226 (1981). https://doi.org/10.1007/BF00413316
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DOI: https://doi.org/10.1007/BF00413316