Summary
The antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6×12 mg/kg per week p.o. reduced the tumor area by 82% (control+192%). D 15413 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse. In vitro, the growth of estrogen receptor positive MCF-7 breast cancer cells was inhibited by D 15413 (10−8–10−5 M). A mode of action considering endocrine and cytotoxic effects is discussed.
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Dedicated to Professor D. Schmähl on the occasion of his 60th birthday
Supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 234, and by the Verband der Chemischen Industrie, Fonds der Chemischen Industrie
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von Angerer, E., Prekajac, J., Schneider, M.R. et al. The inhibitory effect of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors. J Cancer Res Clin Oncol 110, 216–220 (1985). https://doi.org/10.1007/BF00399276
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DOI: https://doi.org/10.1007/BF00399276