Skip to main content
SpringerLink
Log in

Angriffspunkte von Vinca-Alkaloiden im Protein- und Nucleinsäurestoffwechsel

Sites of action of vinca-alcaloids in protein and nucleic acid metabolism

  • Published:
Zeitschrift für Krebsforschung Aims and scope Submit manuscript

Summary

14C-leucine-incorporation by ascites cells is diminished by Vinblastine. RNA-, DNA-and especially proteinbiosynthesis of leukemic lymphocytes are inhibited by Vinblastine and Vincristine. Further, a similar mode of inhibition of proteinbiosynthesis as well as the inactivation of DNA dependent RNA-Polymerase was displayed by cell free systems. The intracellular content of nucleosides was reduced in intact cells.—Similar results have been obtained by employing Colchicine as a reference substance.

Zusammenfassung

Vinblastin senkt den 14C-Leucin-Einbau in Asciteszellen. Vinblastin und Vincristin hemmen die DNS-, RNS-und besonders die Proteinbiosynthese in leukämischen Rinderlymphocyten und führen auch in zellfreien Systemen zu einer Hemmung der Proteinbiosynthese. Im Bereich des Nucleinsäurestoffwechsels inaktivieren sie vornehmlich die DNS-abhängige RNS-Polymerase, in Ganzzellen setzen sie den intracellulären Nucleosidgehalt herab.—Das zum Vergleich eingesetzte Colchicin besitzt ähnliche Angriffspunkte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Creasy, W. A., and E. M. Markiw: The synthesis of ribonucleic acids and the incorporation of amino acids in Ascites cells. Biochim. biophys. Acta (Amst.) 103, 635–645 (1965).

    Google Scholar 

  • : A comparison of the effects of Colchicine, Vinblastine and Vincristine on the synthesis of ribonucleic acids in Ehrlich Ascites cells. Biochim. biophys. Acta (Amst.) 87, 601–609 (1964).

    Google Scholar 

  • Hunter, J. G.: Effects of Vincaleucoblastinesulfate on metabolism of Thioguanine resistant L 1210 Leukemia cells. Biochem. Pharmacol. 12, 283 (1963).

    Google Scholar 

  • Jones, R. G. W., J. F. Richards, and T. C. Beer: Effect of Vinblastine on the biosynthesis of nucleic acids and their precursors in rat Thymus cells. Cancer Res. 26, 882–887 (1966a).

    Google Scholar 

  • : Effect of nucleic acid formation by isolated cell suspensions. Cancer Res. 26, 876–881 (1966b).

    Google Scholar 

  • Lettré, H.: Action of Vincaleucoblastine upon cells in vitro and against Ehrlich Ascites tumours. Excepta Medica International Congress Series No. 106, S. 43–49. Proc. first Symposium European Cancer Chemotherapy Group (G.E.C.A.) Paris, June 1965.

  • Marmont, M. A., and E. E. Damasio: The effects of two alkaloids derived from Vinca Rosea on the malignant cells of Hodgkin's desease, Lymphosarcoma and acute Leukemia in vivo. Hematology 29, 1–21 (1967).

    Google Scholar 

  • Obrecht, P.: Vinca alkaloids. In: Plattner, Pl. A. (Ed.), Chemotherapy of cancer s. 165. Amsterdam. Elsevier 1964.

    Google Scholar 

  • Weitzel, G., F. Schneider, H. Guglielmi, J. Sander, J. Durst u. W.-D. Hirschmann: Untersuchungen zum cytostatischen Wirkungsmechanismus der Methylhydrazine III. Hoppe-Seylers Z. physiol. Chem. 348, 433–442 (1967a).

    Google Scholar 

  • , W. D. Hirschmann, J. Durst, R. Thauer, D. Kummer u. D. Ochs: Untersuchungen zum cytostatischen Wirkungsmechanismus der Methylhydrazine II. Hoppe-Seyler's Z. physiol. Chem. 348, 443–454 (1967b).

    Google Scholar 

  • , D. Kummer u. D. Ochs: Cytostatischer Wirkungsmechanismus von Natulan. Z. Krebsforsch. 70, 354–365 (1968).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Physiologisch-chemisches Institut der Universität Tübingen, Tübingen, Deutschland

    P. Warnecke & S. Seeber

Authors
  1. P. Warnecke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Seeber
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Warnecke, P., Seeber, S. Angriffspunkte von Vinca-Alkaloiden im Protein- und Nucleinsäurestoffwechsel. Z Krebs-forsch 71, 361–367 (1968). https://doi.org/10.1007/BF00524415

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00524415

Search

Navigation