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Effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma

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  • Experimental Oncology
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Summary

The effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma was studied. The i.m. implanted primary tumor was removed on the 10th day after transplantation, and the survival of mice was registered. Cyclophosphamide proved to be the most effective among the drugs studied (Cyclophosphamide, 5-FU, DBD, CCNU, Adriamycin, Vincristin, Hexyldeoxyuridine). Using different schedules (pre- and/or post-operative treatment) the pre- and post-operative drug administration was the most advantageous. Combined therapy showed always better effect than monotherapy.

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Authors and Affiliations

  1. I. Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, Üllői ut. 26, 1085, Budapest, Hungary

    Zs. Szabó, O. Dworák, L. Kopper & K. Lapis

Authors
  1. Zs. Szabó
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  2. O. Dworák
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  3. L. Kopper
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  4. K. Lapis
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Szabó, Z., Dworák, O., Kopper, L. et al. Effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma. J Cancer Res Clin Oncol 97, 161–166 (1980). https://doi.org/10.1007/BF00409902

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  • DOI: https://doi.org/10.1007/BF00409902

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