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Wirkung von Acetylsalicylsäure und einem Pyrido-pyrimidin-Derivat auf die Abstoßung allotransplantierter Nieren im Tierexperiment

The effect of Acetyl-salicylic-acid and a pyrido-pyrimidine-derivate on the rejection of allotransplanted canine kidneys

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Research in Experimental Medicine

Summary

The effects of anti-thrombotic drugs—Acetyl-salicylic-acid and 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-sulfat-trihydrat—on rejection reactions of renal allografts in dogs have been studied. From the clinical point of view no effectiveness of the two drugs can be found, whereas the histological findings do clearly show diminished rejection reactions in the Acetylsalicylic-acid group.

Zusammenfassung

Thrombocytenaggregationshemmende Pharmaka — Acetylsalicylsäure und 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-Sulfattrihydrat—werden in ihrer Wirkung auf Abstoßungsreaktionen bei allotransplantierten Nieren an Hunden untersucht. Klinisch findet sich keine Wirksamkeit der Medikamente, dagegen zeigen interessanterweise die histologischen Befunde bei der Acetylsalicylsäuregruppe eine verminderte Abstoßungsreaktion.

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Abbreviations

ASA:

Acetylsalicylsäure, Colfarit der Fa. Bayer, Leverkusen

PPS:

(2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-Sulfattrihydrat, SH 869 der Fa. Thomae, Biberach (Riß)

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Authors and Affiliations

  1. Urologische Klinik, Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf 1, Bundesrepublik Deutschland

    B. Jennes, W. Wagner, R. Meridies, G. Kollias, E. Jacobi & F. Huth

  2. Pathologisches Institut der Universität Düsseldorf, Moorenstraße 5, D-4000, Düsseldorf 1, Bundesrepublik Deutschland

    B. Jennes, W. Wagner, R. Meridies, G. Kollias, E. Jacobi & F. Huth

Authors
  1. B. Jennes
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  2. W. Wagner
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  3. R. Meridies
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  4. G. Kollias
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  5. E. Jacobi
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  6. F. Huth
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Jennes, B., Wagner, W., Meridies, R. et al. Wirkung von Acetylsalicylsäure und einem Pyrido-pyrimidin-Derivat auf die Abstoßung allotransplantierter Nieren im Tierexperiment. Res. Exp. Med. 165, 67–73 (1975). https://doi.org/10.1007/BF01856451

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  • DOI: https://doi.org/10.1007/BF01856451

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