Summary
The experimental model of the anephric, daily hemodialyzed conscious dog with exclusive parenteral nutrition was realized by means of a closed batch hemodialysis system (Rhodial 75) and a highly permeable polyacrylonitrile membrane (RP 6 dialyzer). Technical details, parenteral feeding, hemodialysis, and amino acid solutions preparation were described to realize a stable condition of the animals for further metabolic analyses during the early anephric period.
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References
Vanatta J, Muirhead EE, Grollman A (1949) Improvements on the artificial kidney: an experimental study of its application to dogs bilaterally nephrectomized or otherwise deprived of renal function. Am J Physiol 156:443
Leonards JR, Heisler CR (1951) Artificial kidney. IV. Maintenance of life in bilaterally nephrectomized dogs and its relation to malignant hypertension. Am J Physiol 167:553
Gourley IM, Parker HR, Bell RL, Ishizaki G (1973) Responses of nephrectomized dogs during hemodialysis. Am J Vet Res 34:1421
Skeggs LT, Leonards JR (1948) Studies on an artificial kidney. I. Preliminary results with a new type of continuous dialyzer. Science 108:212
Grollman A, Muirhead EE, Vanatta J (1949) Role of the kidney in pathogenesis of hypertension as determined by a study of the effects of bilateral nephrectomy and other experimental procedures on the blood pressure of the dog. Am J Physiol 157:21
Grollman A, Turner LB, McLean JA (1951) Intermittent peritoneal lavage in nephrectomized dogs and its application to the human being. Arch Int Med 87:379
Houck CR (1954) Problems in maintenance of chronic bilaterally nephrectomized dog. Am J Physiol 176:175
Draibe S (1978) Hémodialyses repetées chez le chien anéphrique éveillé. Thèse de doctorat (mention Sciences), Université Pierre et Marie Curie, Paris
Conway J (1966) Hemodynamic consequences of induced changes in blood volume. Circ Res 18:190
Sausse A, Granger A, Man NK, Funck-Brentano JL (1974) Un nouveau rein artificiel. La Nouvelle Presse Méd 3:957
National Research Council (1962) Committee on Animal Nutrition. Natl Acad Sci NRC Publ:989–9
Bergström J, Asaba H, Fürst P, Oules R (1976) Dialysis, ultrafiltration, and blood pressure. Proc Eur Dial Transplant Assoc 10:293
Rose WC (1949) Amino acid requirements of man. Fed Proc 8:546
Hyne BEB, Fowell E, Lee HA (1972) The effect of caloric intake on nitrogen balance in chronic renal failure. Clin Sci 43:679
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Dr. P. Pils' stay in the Hôpital Necker was granted by the Collège de Médecine, Paris, and the Österreichische Bundesministerium für Wissenschaft und Forschung
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Pils, P., Draibe, S., Liard, J.F. et al. Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs. Res. Exp. Med. 177, 119–124 (1980). https://doi.org/10.1007/BF01851840
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DOI: https://doi.org/10.1007/BF01851840