Summary
The antisecretory effects of a new histamine H2-receptor antagonist, ranitidine hydrochloride, have been investigated on basal and pentagastrinstimulated acid secretion in healthy volunteers 5 and 10 h after oral administration of 150 mg. In addition, the 24-h intragastric pH-profiles have been measured in patients undergoing parenteral nutrition after three doses of 150 mg ranitidine per day.
A 40% inhibition of basal acid output has been noted even 10 h after drug intake. The intragastric pH-values were raised above 5 for at least 24h.
The new H2-antagonist ranitidine has been proven to be a potent and longacting antisecretory compound.
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Dammann, H.G., Müller, P., Kather, H. et al. The new histamine H2-receptor antagonist ranitidine. Res. Exp. Med. 178, 151–154 (1981). https://doi.org/10.1007/BF01851489
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DOI: https://doi.org/10.1007/BF01851489