Summary
Hepatic energy charge ((ATP+1/2ADP)/(ATP+ADP+AMP)) and arterial blood ketone body ratio (acetoacetate/3-hydroxybutyrate) were measured after hepatic artery embolization in carbon-tetrachloride-induced cirrhotic rats. In normal livers, energy charge slightly decreased at 3 h and returned to normal levels at 6 h. By contrast, in cirrhotic livers, energy charge was drastically decreased at 3 h after embolization and was not completely recovered at 6h. Blood ketone body ratio, reflecting hepatic mitochondrial redox (NAD+/NADH) state, also decreased at 3 h after embolization in both groups, and its recovery was not observed in cirrhotic group at 6 h.
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Taki, Y., Jikko, A., Morimoto, T. et al. Effect of hepatic artery embolization on the adenylate energy charge level and the redox state of the cirrhotic liver. Res. Exp. Med. 186, 179–183 (1986). https://doi.org/10.1007/BF01852043
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DOI: https://doi.org/10.1007/BF01852043