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Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release

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Research in Experimental Medicine

Summary

The influence of circulating catecholamines on the release of pancreatic polypeptide (PP) and gastrin was studied in volunteers. Physical exercise increased plasma epinephrine by 374 ± 123% and plasma norepinephrine by 167 ± 30%, but plasma PP concentrations remained unchanged during standardized bicycle ergometry. Immediately after cessation of exercise catecholamine levels decreased rapidly, whereas PP concentrations increased by 55%. In a second series, epinephrine infusion (5, 25, and 75 ng · kg−1 · min−1) increased epinephrine levels by 38 ± 12, 331 ± 69, and 1229 ± 131%, respectively, whilst norepinephrine was unaffected. Neither during nor after catecholamine infusion PP secretion was affected. Gastrin release increased by a maximum of 85 ± 38% (at epinephrine 75 ng · kg−1 · min−1). It is concluded, that (1) changes in circulating adrenaline do not significantly influence PP secretion in man; (2) the PP increase immediately following physical exercise cannot be attributed to a rapid fall of catecholamine levels; (3) endogenous catecholamines are of minor importance in the control of gastrin secretion.

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Authors and Affiliations

  1. Divisions of Gastroenterology and Endocrinology, Dept. of Medicine, Philipps University, Baldingerstraße, D-3550, Marburg, Federal Republic of Germany

    H. Mönnikes, H. Koop, K. Ehlenz, J. Dionysius & R. Arnold

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  1. H. Mönnikes
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  2. H. Koop
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  3. K. Ehlenz
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  4. J. Dionysius
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  5. R. Arnold
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Supported by the Kempkes Stiftung, Marburg, and the Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg, grant Ko 847/1-3

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Mönnikes, H., Koop, H., Ehlenz, K. et al. Role of circulating catecholamines in the control of pancreatic polypeptide and gastrin release. Res. Exp. Med. 189, 181–187 (1989). https://doi.org/10.1007/BF01852166

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  • DOI: https://doi.org/10.1007/BF01852166

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