Summary
Migratory behaviour of Ancylostoma braziliense was studied in relation to the structure of the skin in dogs after primary infections.
Data were obtained studying serial sections of lateral skin areas 6 mm in diameter, which had been exposed to larvae. The sections were stained either with Harris' haematoxylin and eosin or with P.A.S. or as outlined by Crossmon.
Most of the larvae managed to penetrate the skin within 1/2 hr after the application.
Hairs did not seem to constitute sites of entry. The larvae moved into the horny layer where edges of keratinized cells provide uneven spots. They migrated approximately parallel to the surface from the horny layer into the living epidermis and continued into an external root sheath of a hair follicle. They could only leave this site via sebaceous glands for the dermis or via apocrine sweat glands for the hypodermis. Tunnels from the epidermis into the dermis, however, suggested that a direct trans-epidermal migration had occurred. The vessels invaded by larvae were hypodermal lymphatic vessels. The first ones were found in these structures 1/2 h after the onset of the exposure.
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References
Fülleborn, F.: Durch Hakenwurmlarven des Hundes (Uncinaria stenocephala) beim Menschen erzeugte “Creeping Eruption”. Abhandlungen aus dem Gebiet der Auslandkunde, Hamburgische Universität, Band 26, Reihe D, Medizin Band 2, 121–133 (1927)
Kirby-Smith, J.L., Dove, W.E., White, G.F.: Creeping eruption. Arch. Derm. Syph. 13, 137–173 (1926)
Looss, A.: The anatomy and life history of Agchylostoma duodenale. Dub. Records of the School of Medicine, Cairo, Egypt IV (1911)
Matthews, B.E.: Invasion of skin by larvae of the cat hookworm, Ancylostoma tubaeforme. Parasitology 65, 457–467 (1972)
McManus, J.F.A., Mowry, R.W.: Staining methods. New York, Evanston, London: Harper & Row; Tokyo: Weatherhill 1964
Norris, D.E.: The migratory behaviour of the infective-stage larvae of Ancylostoma braziliense and Ancylostoma tubaeforme in rodent paratenic hosts. J. Parasit. 5, 998–1009 (1971)
Pearse, A.G.: Histochemistry I. London: Churchill 1968
Rep, B.H.: The pathogenity of Ancylostoma brazilliense. II. Cultivation of hookworm larvae. Trop. geogr. Med. 17, 329–337 (1965)
Romeis, B.: Mikroskopische Technik. München, Wien: Oldenburg 1968
Standen, O.D.: The penetration of the cercariae of Schistosoma mansoni into the skin and lymphatics of the mouse. Trans. roy. Soc. trop. Med. Hyg. 47, 292–298 (1953)
Stirewalt, M.A.: Skin penetration mechanisms of helminths. In: Biology of parasites, E.J.L. Soulsby, ed., pp. 41–59. New York and London: Academic Press 1966
Stirewalt, M.A., Dorsey, C.H.: Schistosoma mansoni: Cercarial penetration of host epidermis at the ultrastructural level. Exp. Parasit. 35, 1–15 (1974)
Stirewalt, M.A., Hackey, J.R.: Penetration of host skin by cercariae of Schistosoma mansoni. I. Observed entry into skin of mouse, hamster, rat, monkey and man. J. Parasit. 42, 565–580 (1956)
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Vetter, J.C.M., Leegwater-v.d. Linden, M.E. Skin penetration of infective hookworm larvae. Z. F. Parasitenkunde 53, 255–262 (1977). https://doi.org/10.1007/BF00389941
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DOI: https://doi.org/10.1007/BF00389941