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The human PGM-2 and its chromosomal localization in man-mouse hybrids

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Summary

A detailed procedure is described for a rapid detection of phosphoglucomutase-2 (=phosphopentomutase; PGM-2) on Cellogel following electrophoresis of extracts of human red blood cells and other tissues, including cultured fibroblasts and various types of primate-rodent somatic hybrid cells.

The present study indicated that there is only one locus for phosphopentomutase in man. The data from a selected panel of 20 independent clones of man-mouse somatic cell hybrids, investigated for the presence of human chromosomes and for the presence or absence of human PGM-2 favored the assignment of the human PGM-2 locus to chromosome 4.

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Authors and Affiliations

  1. Department of Human Genetics, State University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands

    Lucie M. M. Wijnen, P. L. Pearson & P. Meera Khan

  2. Institut für Humangenetik der Universität Münster, D-4400, Münster, Federal Republic of Germany

    K. -H. Grzeschik

Authors
  1. Lucie M. M. Wijnen
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  2. K. -H. Grzeschik
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  3. P. L. Pearson
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  4. P. Meera Khan
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Wijnen, L.M.M., Grzeschik, K.H., Pearson, P.L. et al. The human PGM-2 and its chromosomal localization in man-mouse hybrids. Hum Genet 37, 271–278 (1977). https://doi.org/10.1007/BF00393608

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  • DOI: https://doi.org/10.1007/BF00393608

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