Summary
The localization of the structural gene for human α-galactosidase B (=N-acetyl-α-galactosaminidase) was investigated by means of man-Chinese hamster and man-mouse somatic cell hybrids. The hybrid clones were analyzed for chromosomes and for a large number of known enzyme markers. The lysates of the hybrid cells were treated with Sepharose-coupled antihuman α-galactosidase B and the activity of the adsorbed enzyme was measured on the Sepharose beads as N-acetyl-α-galactosominidase. The results show that the structural gene for human α-galactosidase B is situated on chromosome 22, and that there is no structural relationship between human α-galactosidase A and human α-galactosidase B.
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de Groot, P.G., Westerveld, A., Khan, P.M. et al. Localization of a gene for human α-galactosidase B (=N-Acetyl-α-D-Galactosaminidase) on chromosome 22. Hum Genet 44, 305–312 (1978). https://doi.org/10.1007/BF00394295
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DOI: https://doi.org/10.1007/BF00394295