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The testis as a secretory organ for H-Y antigen

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Summary

After cultivation of dissociated rat testicular tissues, H-Y antigen is detectable in the medium; this is not the case if nongonadal male tissues are incubated. Release of H-Y antigen by testis cells is inhibited by the addition of cycloheximide. All tissues still type H-Y positive after culture. It is assumed that the testis actively secretes H-Y antigen. This assumption is supported by the finding that the amount of H-Y antigen in the epididymal fluid increases with the age of the animals.

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References

  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J.: Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 165–275 (1951)

    Google Scholar 

  • Moscona, A. A., Hausman, R. E.: Biological and biochemical studies on embryonic cell-cell recognition. In: Cell and tissue interactions (J. W. Lash, M. M. Burger, eds.), pp. 173–185. New York: Raven 1977

    Google Scholar 

  • Müller, U., Aschmoneit, I., Zenzes, M. T., Wolf, U.: Binding studies of H-Y antigen in rat tissues; indications for a gonad specific receptor. Hum. Genet. 43, 151–157 (1978a)

    Google Scholar 

  • Müller, U., Zenzes, M. T., Bauknecht, T., Wolf, U., Siebers, J. W., Engel, W.: Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro. Hum. Genet. (in press, 1978b)

  • Ohno, S., Nagai, Y., Ciccarese, S.: Testicular cells lysostripped of H-Y antigen organize ovarian follicle-like aggregates. Cytogenet. Cell Genet. 20, 351–364 (1978)

    Google Scholar 

  • Scheid, M., Boyse, E. A., Carswell, E. A., Old, L. J.: Serologically demonstrable alloantigens of mouse epidermal cells. J. Exp. Med. 135, 938–955 (1972)

    Google Scholar 

  • Zenzes, M. T., Wolf, U., Engel, W.: Organization in vitro of ovarian cells into testicular structures. Hum. Genet. 44, 333–338 (1978a)

    Google Scholar 

  • Zenzes, M. T., Wolf, U., Günther, E., Engel, W.: Studies on the function of H-Y antigen: Dissociation and reorganization experiments on rat gonadal tissue. Cytogenet. Cell Genet. 20, 365–372 (1978b)

    Google Scholar 

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Authors and Affiliations

  1. Institut für Humangenetik und Anthropologie, Albertstr. 11, D-7800, Freiburg i. Br., Federal Republic of Germany

    U. Müller, Maria Teresa Zenzes & U. Wolf

  2. Frauenklinik der Universität Freiburg i. Br., D-7800, Freiburg i. Br., Federal Republic of Germany

    J. W. Siebers

Authors
  1. U. Müller
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  2. J. W. Siebers
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  3. Maria Teresa Zenzes
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  4. U. Wolf
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Müller, U., Siebers, J.W., Zenzes, M.T. et al. The testis as a secretory organ for H-Y antigen. Hum. Genet. 45, 209–213 (1978). https://doi.org/10.1007/BF00286965

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  • DOI: https://doi.org/10.1007/BF00286965

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