Summary
During the transition between the fetal and postnatal periods associations between cell junctions and cell organelles appear in the liver of the mouse. These associations are of two types: desmosome-organelle and nexus-organelle.
1.Nexus-Organelles Association. Unilaterally or bilaterally, various organelles — mitochondria, cysternae, microbodies or lysosomes — adhere tightly along the gap. These associations appear only between the 21st day of gestation and the first postnatal day. Thereafter they gradually disappear and are replaced by desmosome-organelle associations. Another type of structure — ergastoplasmic saccules or cisternae of rough endoplasmic reticulum — become associated with the cell membrane.
2.Desmosome-Organelle Associations. In these complexes the desmosomal microfilaments are in close contact with membranes of the associated organelles — mitochondria or peroxysomes. The associations, which exist as early as the 13th day of gestation increase after the first postnatal day.
The significance of these associations remains to be ascertained, especially since they occur in many other tissues. A few hypotheses are presented.
Résumé
Au cours du passage de la vie foetale à la vie postnatale, on note, dans le foie de souris, l'apparition d'associations jonctions-organites cellulaires. Celles-ci cont de deux types: associations desmosomes-organites et associations nexus-organites.
1.Associations nexus-organites. Le long de la «gap junction» sont étroitement accolés, uni ou bilatéralement, divers organites: mitochondrie(s), subsurface cisterna(e), peroxysome(s) ou lysosome. Ces associations n'apparaissent qu'entre le 21ème jour de la gestation et le ler jour post-natal, période à partir de laquelle ils disparaissent au profit d'associations desmosomes-organites cellulaires. Un nouveau type de structure s'associe dans le foie aux membranes plasmatiques: il s'agit des saccules ergastoplasmatiques ou subsurface cisternae.
2.Associations desmosomes-organites. Dans ces complexes, les tonofilaments desmosomiques entrent étroitement en contact avec la paroi des organites cellulaires associés: mitochondrie ou peroxysome. Déjà présents au 13ème jour de la gestation, ces structures s'observent plus fréquemment à partir du ler jour post-natal.
La signification de ces associations reste à déterminer, d'autant plus que leur présence a déjà été signalée dans de trés nombreux tissus. Quelques hypothèses sont présentées.
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Références
Berger, E. R.: Subsurface membranes in paired cone photoreceptor inner segments of adult and neonatal Lebistes retinae. J. Ultrastruct. Res. 17, 220–232 (1967).
Bischoff, M. B., Richter, W. R., Stein, R. J.: Ultrastructural changes in pig hepatocytes during the transitional period from late foetal to early neonatal life. J. Cell Sci. 4, 381–395 (1969).
Campbell, R. D., Campbell, J. H.: Origin and continuity of desmosomes. In: Origin and continuity of cell organelles, (J. Reinert, H. Ursprung, eds.) p. 261–298. Berlin-Heidelberg-New York: Springer Verlag 1971.
Deane, H. W., Wurzelmann, S.: Mitochondrial desmosome complexes in various differentiating epithelia. Proc. 6th Internat. Congr. Electron Micr. Kyoto 1966 (R. Uyeda, ed.), p. 403–404. Tokyo: Maruzen Co 1966.
Dvorak, M.: Beitrag zur Karyometrie der Leberzellen in der embryonalen und der frühen postnatalen Periode [Tschechisch.]. Scr. med. 36, 149–159 (1963).
Dvorak, M., Mazanec, K.: Differenzierung der Feinstruktur der Leberzelle in der frühen postnatalen Periode. Z. Zellforsch. 80, 379–384, (1967).
Franke, H., Goetze, E.: Die Feinstruktur der Leberzellen von Rattenfoeten und Neugeborenen in verschiedenen Entwicklungsstadien. Acta biol. med. germ. 11, 424–432 (1963).
Joyon, L., Malet, P., Turchini, J. P.: Structures et rapports particuliers des mitochondries avec les membranes plasmatiques d'hépatocytes de nouveau-nés. C. R. Acad. Sci. (Paris) 259, 2532–2534 (1964).
Kalashnikova, M. M.: Changes in the ultrastructure of rat liver parenchymal cells in postnatal ontogenese. Proc. 7th Int. Congr. Electron Micr. Grenoble 1970 (P. Favard, ed.), p. 487–488.
Karnovsky, M. J.: A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron microscopy. J. Cell Biol. 27, 137A-138A (1965).
Kumegawa, M., Cattoni, M., Rose, G. G.: Electron microscopy of oral cells in vitro. II. Subsurface and intracytoplasmic confronting cisternae in strain KB cells. J. Cell Biol. 36, 443–452 (1968).
Ladman, A. J.: The fine structure of the ductuli efferentes of the opossum. Anat. Rec. 157, 559–576 (1967).
Ma, M. H., Biempica, L.: The normal human liver cell. Cytochemical and ultrastructural studies. Amer. J. Path. 62, 353–390 (1971).
Malet, P., Perissel, B., Turchini, J. P.: Quelques caractères ultrastructuraux des jonctions interhépatocytaires périnatales (Souris, Rat). Données morphologiques préliminaires. J. Microscopie 14, 17–26 (1972).
Noirot-Timothée, C., Noirot, C.: Liaison de mitochondries avec des zones d'adhésion intercellulaires. J. Microscopie 6, 87–90 (1967).
Nunez, E. A.: Secretory processes in follicular cells of the bat thyroid. II. The occurence of organelle-associated intercellular junctions during late hibernation. Amer. J. Anat. 131, 227–240 (1971).
Overton, J.: Desmosome development in normal and reassociating cells in the early chick blastoderm. Develop. Biol. 4, 532–548 (1962).
Peters, V. B., Kelly, G. W., Dembitzer, H. M.: Cytological changes in fetal and neonatal hepatic cells of the mouse. Ann. N. Y. Acad. Sci. 111, 87–103 (1963).
Revel, J. P., Karnovsky, M. J.: Hexagonal array of subunits in intercellular junctions of the mouse heart and liver. J. Cell Biol. 33, C7-C12 (1967).
Reynolds, E. S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208–212 (1963).
Rohr, H. P., Wirz, A.: Ultrastrukturell-morphometrische Untersuchungen an der perinatalen Rattenleberparenchymzelle. Morphometric analysis of the rat liver cell in the perinatal period. Verh. dtsch. Ges. Path. 54, 505–510 (1970).
Rohr, H. P., Wirz, A., Henning, L. C., Riede, U. N., Bianchi, L.: Morphometric analysis of the rat liver cell in the perinatal period. Lab. Invest. 24, 128–139 (1971).
Rosenbluth, J.: Subsurface cisterns and their relationship to the neuronal plasma membrane. J. Cell Biol. 13, 405–421 (1962).
Sternlieb, I.: Mitochondrion-desmosome complexes in human hepatocytes. Z. Zellforsch. 93, 249–253 (1969).
Tandler, B., Hoppel, C. L.: Peroxysome-desmosome complexes in mouse hepatic cells. Z. Zellforsch. 110, 166–172 (1970).
Turchini, J. P., Malet, P., Bourges, M.: Foie néo-natal. Notes de cytologie (Hépatocytes: détails d'infrastructure, II). C. R. Ass. Anat., 53ème Congrès, Tours, 143, 1655–1663 (1968).
Weis, P.: Confronting subsurface cisternae in chick embryo spinal ganglia. J. Cell Biol. 39, 485–488 (1968).
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Nous remercions Mme F. Mandon, MM. R. Flageolet et M. Pezaire pour l'excellente assistance technique qu'ils nous ont apportée.
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Perissel, B., Malet, P. & Geneix, A. Associations jonctions-organites cellulaires dans le foie néo-natal de souris. Z.Zellforsch 140, 77–89 (1973). https://doi.org/10.1007/BF00307059
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DOI: https://doi.org/10.1007/BF00307059