Summary
The distribution and structure of the ureteric nerves in a small series of mammals was compared with that previously demonstrated in the rat. There was marked interspecies variation in the extent to which the nerves penetrated the wall of the ureter and in the degree of development of the deep submucous plexus. In animals with a highly developed deep submucous plexus, terminal arterioles frequently passed through the muscle coat before breaking up into capillaries. These vessels were surrounded by a fine periarteriolar plexus and were accompanied in their course through the muscle coat by one or more branches of the adventitial nerves. Intramuscular nerves not related to arterioles contained few axons with terminals classifiable as either adrenergic or cholinergic, and in animals in which the muscle cells were arranged in fascicles rather than in sheets, the nerves were typically interfascicular in position. As in the rat, only the periarteriolar plexuses contained large numbers of adrenergic axons. Cholinergic axons were generally few, but were not uncommon in the deep submucous plexus when this was well-developed. The majority of the terminals encountered in the intramural nerves contained variable and usually small numbers of both clear and large dense-cored vesicles. The relationship between these terminals and those defined in the submucous nerves of the rat ureter was discussed and it was suggested that the marked variations in the diameter of the axons in the terminal areas and in the number of vesicles in the terminals were related to the effects of the mechanical and other derangements which occur during processing.
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References
Aung-Khin, M.: The innervation of the ureter. Invest. Urol. 10, 370–378 (1972)
Dixon, J. S., Gosling, J. A.: Histochemical and electron microscopic observations on the innervation of the upper segment of the mammalian ureter. J. Anat. (Lond.) 110, 57–66 (1971)
Duarte-Escalante, O., Labay, P., Boyarsky, S.: The neurohistochemistry of mammalian ureter: A new combination of histochemical procedures to demonstrate adrenergic, cholinergic and chromaffin structures in the ureter. J. Urol. (Baltimore) 101, 803–811 (1969)
Elbadawi, A., Schenk, A. E.: Dual innervation of the mammalian bladder. A histochemical study of the distribution of cholinergic and adrenergic nerves. Amer. J. Anat. 119, 405–428 (1966)
Elbadawi, A., Schenk, A. E.: Innervation of the abdominopelvic ureter in the cat. Amer. J. Anat. 126, 103–120 (1969)
Gosling, J. A., Dixon, J. S.: Catecholamine-containing nerves in the submucosa of the ureter. Experientia (Basel) 27, 1065–1066 (1971)
Gosling, J. A., Dixon, J. S.: The effect of 6-hydroxydopamine on nerves in the rat upper urinary tract J. Cell Sci. 10, 197–209 (1972)
Gosling, J. A., Dixon, J. S.: Sensory nerves in the mammalian urinary tract. An evaluation using light and electron microscopy. J. Anat. (Lond.) 117, 133–144 (1974)
Hoyes, A. D., Bourne, R., Martin, B. G. H.: Ultrastructure of the submucous nerves of the rat ureter. J. Anat. (Lond.) 123-132 (1975a)
Hoyes, A. D., Bourne, R., Martin, B. G. H.: Ureteric vascular and muscle coat innervation in the rat. A quantitative ultrastructural study. (1975b, submitted for publication)
Karnovsky, M. J.: A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J. Cell Biol. 27, 137A (1965)
Ogata, J., Ueno, F., Sakata, T., Yamasaki, K.: Histochemical study of adrenergic and cholinergic nerve fibres in the dog ureter. Kumamato med. J. 26, 113–119 (1973)
Schulman, C. C., Duarte-Esoalante, O., Boyarsky, S.: The ureterovesical innervation. A new concept based on a histochemical study. Brit. J. Urol. 44, 698–712 (1972)
Wein, A. J., Leoni, J. V., Schoenberg, H. W., Jacobowitz, D.: A study of the adrenergic nerves in the dog ureter. J. Urol. (Baltimore) 108, 232–233 (1972)
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Hoyes, A.D., Barber, P. & Martin, B.G.H. Comparative ultrastructure of ureteric innervation. Cell Tissue Res. 160, 515–524 (1975). https://doi.org/10.1007/BF00225768
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DOI: https://doi.org/10.1007/BF00225768