Summary
The marginal sinus in the spleen of the Wistar rat surrounds the follicle and has more numerous PAS positive fibers on the inner wall than on the outer wall. India ink- and lead oxide-gelatin were injected into the abdominal aorta. It was found that much of the india ink-gelatin accumulated in the marginal sinus, the marginal zone, and part of the red pulp, while most of the lead oxide-gelatin collected in the marginal sinus.
Ultrastructurally, the capillaries of the follicle were found to open into the marginal sinus. Regions not perforated by the marginal sinus lie between the follicle and the marginal zone. The wall of the marginal sinus is discontinuous and the discontinuities are wider on the marginal zone side than on the follicle side. The relationship of these findings is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abe, K., Ito, T.: Early events in the splenic lymphoid tissue and mesenteric lymph node after a single typhoid-paratyphoid vaccine injection in the mouse, with special reference to the topographic cellular changes in the early immune response. Arch. hist. jap. 34, 471–489 (1972)
Altschul, R., Hummason, F.A.: Minimal vascular injection of the spleen. Anat. Rec. 97, 259–264 (1947)
Andrew, W.: Age changes in the vascular architecture and cell content in the spleens of 100 Wistar Institute rats, including comparisons with human material. Amer. J. Anat. 79, 1–74 (1946)
Berman, V.D., Dornfest, B.S., Handler, E.S., Handler, E.E.: Microangiographic study of the splenic arterial vascularization in the normal and leukemic rat spleen. J. Reticuloendothel. Soc. 12, 449–461 (1972)
Brown, J.C., Harris, G., Papamichail, M., Šlijibić, V.S., Holborow, E.J.: The localization of aggregated human γ-globulin in the spleen of normal mice. Immunology 24, 955–968 (1973)
Burke, J.S., Simon, G.T.: Electron microscopy of the spleen. I. Anatomy and microcirculation. Amer. J. Path. 58, 127–155 (1970)
Clarke, J.M., Weiss, L.: Effects of a bacterial vaccine on the marginal zone of the spleen. Amer. J. Anat. 132, 79–92 (1971)
Congdon, C.C.: The early histologic effects of antigenic stimulation. Arch. Path. 78, 83–96 (1964)
Hayes, T.G.: The marginal zone and marginal sinus in the spleen of the gerbil. A light and electron microscopic study. J. Morph. 141, 205–216 (1973)
Katsura, S., Satodate, R., Fukuda, Y., Terui, Y.: Morphological studies on the reticuloendothelial system in tumor-bearing hosts: 1. Silver impregnation for reticuloendothelial cells. J. Iwate med. Ass. 16, 232–236 (1964)
MacNeal, W.J.: The circulation of blood through the spleen pulp. Arch. Path. 7, 215–227 (1929)
Mitchell, J.: Lymphocyte circulation in the spleen. Marginal zone bridging channels and their possible role in cell traffic. Immunology 24, 93–107 (1973)
Mitchell, J., Abbot, A.: Antigens in immunity. XVI. A light and electron microscope study of antigen localization in the rat spleen. Immunology 21, 207–224 (1971)
Moore, R.D., Mumaw, V.R., Schoenberg, M.D.: The structure of the spleen and its functional implications. Exp. molec. Path. 3, 31–50 (1964)
Nossal, G.J.V., Austin, G.M., Pye, J., Mitchell, J.: Antigens in immunity. XII. Antigen trapping in the spleen. Int. Arch. Allergy 29, 368–383 (1966)
Rooijen, N. van: The vascular pathways in the white pulp of the rabbit spleen. Acta morph. neerl.-scand. 10, 351–357 (1972)
Rooijen, N. van: Mechanism of follicular antigen trapping. Migration of antigen-antibody complexes from marginal zone towards follicle centres. Immunology 25, 847–852 (1973)
Satodate, R., Ogasawara, S., Sasou, S., Katsura, S.: Characteristic structure of the splenic white pulp of rats. J. reticuloendothel. Soc. 10, 428–433 (1971)
Snook, T.: A comparative study of the vascular arrangements in mammalian spleens. Amer. J. Path. 87, 31–77 (1950)
Snook, T.: The histology of vascular terminations in the rabbit's spleen. Anat. Rec. 130, 711–729 (1958)
Snook, T.: Studies on the perifollicular region of the rat's spleen. Anat. Rec. 148, 149–159 (1964)
Thoma, R.: Der normale Blutstrom und die venöse Stauung in der Milz. Virchows Arch. path. Anat. 249, 100–117 (1924)
Veerman, A.J.P., Ewijk, W. van: White pulp compartments in the spleen of rats and mice. A light and electron microscopic study of lymphoid and non-lymphoid cell types in T- and B-areas. Cell Tiss. Res. 156, 417–441 (1975)
Veerman, A.J.P., Rooijen, N. van: Lymphocyte capping and lymphocyte migration as associated events in the in vivo antigen trapping process. An electron-microscopic autoradiographic study in the spleen of mice. Cell Tiss. Res. 161, 211–217 (1975)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sasou, S., Satodate, R. & Katsura, S. The marginal sinus in the perifollicular region of the rat spleen. Cell Tissue Res. 172, 195–203 (1976). https://doi.org/10.1007/BF00226027
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00226027