Summary
Cells of the HeLa strain show considerable activity of nuclear movements in the fashion of complete rotation, incomplete rotation and rocking. The activity decreases when the culture becomes older but changing fresh medium restores it. Approximately two-thirds of the cells entering division show premitotic movements, mostly of the rocking type.
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Literature
Frey-Wyssling, A.: Submicroscopic morphology of protoplasm and its derivatives. New York u. Amsterdam: Elsevier 1948.
Hsu, T. C.: Cytological studies on HeLa, a strain of human cervical carcinoma. I. Observations on mitosis and chromosomes. Texas Rep. Biol. a. Med. 12 (1954) (im Druck).
Hughes, A.: The mitotic cycle. London: Butterworths 1952.
Merton, H.: Untersuchungen über Entstehung und Natur des Kinoplasmas in den Zwitterdrüsen der Pulmonaten. Z. Zellforsch. 13, 202–235 (1931).
Penard, E.: Faune rhizopodique du bassin du Léman. Genève 1902.
Pomerat, C. M.: Rotating nuclei in tissue cultures of adult human nasal mucosa. Exper. Cell. Res. 5, 191–196 (1953).
Prell, H.: Zur Theorie der Sekretorischen Ortsbewegung. II. Die Bewegung der Gregarinen. Arch. Protistenkde 42, 157–175 (1921).
Scherer, W. F., J. T. Syverton and G. O. Gey: Studies on the propagation in vitro of poliomyelitis viruses. IV. Viral multiplication in a stable strain of human malignant epithelial cells (Strain HeLa) derived from an epidermoid carcinoma of the cervix. J. of Exper. Med. 97, 695–710 (1953).
Seifritz, W.: Rheology in cells, p. 106. In: Deformation and flow in biological systems. New York: Interscience 1952.
—: Le mécanisme des movements protoplasmiques. Rev. Cytol. et Biol. végét. 14, 31–37 (1953).
Tahmisian, T. N., A. M. Brues and G. Svihla: Koto-oscillation of the living egg nucleus of Melanoplus differential is: a phase contrast cinemato-micrographic study (motion picture). Amer. J. Physiol. 171, 772 (1952).
Valkanov, A.; Die Natur und die systematische Stellung der Labirhyntuleen. Arch. Protistenkde 67, 110–121 (1929).
—: Über die kinetische Energie einiger Zellbestandteile. Protoplasma (Berlin) 20, 20–30 (1934).
Villa, L., E. Polli and L. Bussi: Alcuni problemi della struttura del nucleo di cellule ematiche. Roma: Edizioni mediche e scientifiche 1953.
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Supported in part by a grant-in aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council and in part by a contract from the Office of Naval Research N6onr-266 T.O. 5.
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Leone, V., Hsu, T.C. & Pomerat, C.M. Cytological studies on HeLa, a strain of human cervical carcinoma. Zeitschrift für Zellforschung 41, 481–492 (1955). https://doi.org/10.1007/BF00345357
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DOI: https://doi.org/10.1007/BF00345357