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Pediatric clinical use of the ketoconazole/cyclosporin interaction

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Abstract

Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.

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References

  1. Hall BM, Tiller DJ, Hardic I, Hahony J, Mathew T, Thatcher G, Miach P, Thomson N, Sheil R (1988) Comparison of three immunosuppressive regimens in cadaver renal transplantation: longterm cyclosporin, short-term cyclosporin followed by azathioprine and prednisolone, and azathioprine and prednisolone with cyclosporin. N Engl J Med 318: 1499–1507

    Google Scholar 

  2. Hoyer PF, Brodehl J, Ehrich JHH, Offner G (1991) Practical aspects in the use of cyclosporin in paediatric nephrology. Pediatr Nephrol 5: 630–638

    Google Scholar 

  3. Brown MW, Maldonado AL, Meredith CG, Speeg KV (1985) Effect of ketoconazole on hepatic oxidative drug metabolism. Clin Pharmacol Ther 37: 290–297

    Google Scholar 

  4. First MR, Schroeder TJ, Michael A, Hariharan S, Weiskittel P, Alexander JW (1993) Safety and efficacy of long-term cyclosporin-ketoconazole administration and preliminary results of a randomized trial. Transplant Proc 25: 591–594

    Google Scholar 

  5. First MR, Schroeder TJ, Alexander JW, Stephens GW, Weiskittel P, Myre SA, Pesce AJ (1991) Cyclosporin dose reduction by ketoconazole administration in renal transplant recipients. Transplantation 51: 365–370

    Google Scholar 

  6. First MR, Weiskittel P, Alexander JW, Schroeder TJ, Myre SA, Pesce AJ (1989) Concomitant administration of cyclosporin and ketoconazole in renal transplant patients. Lancet I: 198–201

    Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Pharmacology/Toxicology Department of Pharmacy and Research Institute, The Hospital for Sick Children, 555 University Avenue, M5G 1X8, Toronto, Ontario, Canada

    M. Berkovitch, D. Matsui, H. Finkelstein & G. Koren

  2. Division of Nephrology, Department of Pharmacy and Research Institute, The Hospital for Sick Children, Torono, Canada

    M. Bitzan & J. W. balfe

Authors
  1. M. Berkovitch
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  2. M. Bitzan
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  3. D. Matsui
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  4. H. Finkelstein
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  5. J. W. balfe
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  6. G. Koren
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Berkovitch, M., Bitzan, M., Matsui, D. et al. Pediatric clinical use of the ketoconazole/cyclosporin interaction. Pediatr Nephrol 8, 492–493 (1994). https://doi.org/10.1007/BF00856546

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  • DOI: https://doi.org/10.1007/BF00856546

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