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Future of the management of emesis

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Abstract

Development of effective antiemesis had depended upon identification of critical neurotransmitter receptors within the emetic reflex arc. Investigations of cholinergic, histaminergic, dopaminergic, and serotonergic receptors led to our present generation of antiemetics. Opiate and adrenergic receptors are the likely targets of the next generation of antiemetics. The recently identified critical neurotransmitter receptors (opiate, adrenergic, and serotonergic) also provide a link to cancer pain, anticipatory vomiting, and cancer anorexia respectively. Future collaborations are likely to include investigators from various areas of supportive care working together on these common problems.

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References

  1. Allan SG, Cornbleet MA, Warrington PSA, Golland IM, Leonard RCF, Smyth JN (1984) Dexamethasone and high dose metoclopramide: efficacy in controlling cisplatin induced nausea and vomiting. Br Med J 289:878–879

    Google Scholar 

  2. Baltzer L, Kris MG, Hinkley L, et al (1994) Reversible electrocardiographic interval prolongations following the specific serotonin antagonists ondansetron and dolasetron mesylate: a possible drug class effect without sequelae? Proc ASCO 13:433

    Google Scholar 

  3. Barnes NM, Bunce KT, Naylor RJ, Rudd JA (1991) The actions of fentanyl to inhibit drug-induced emesis. Neuropharmacology 30:1073–1083

    Google Scholar 

  4. Bhandari P, Bingham S, Andrews PLR (1992) The neuropharmacology of loperamide-induced emesis in the ferret: the role of the area postrema, vagus, opiate and 5-HT3 receptors. Neuropharmacology 31:735–742

    Google Scholar 

  5. Borison HL, Wang SC (1953) Physiology and pharmacology of vomiting. Pharmacol Rev 5:193–230

    Google Scholar 

  6. Fozard JR, Mobarok Ali AT (1978) Blockade of neuronal tryptamine receptors by metoclopramide. Eur J Pharmacol 49:109–112

    Google Scholar 

  7. Gralla RJ, Itri LM, Pisko SE, et al (1981) Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. N Engl J Med 305:905–909

    Google Scholar 

  8. Grunberg SM, Stevenson LL, Russell CA, McDermed JE (1989) Dose ranging phase I study of the serotonin antagonist GR38032F for prevention of cisplatin-induced nausea and vomiting. J Clin Oncol 7:1137–1141

    Google Scholar 

  9. Herrstedt J, Jeppesen BH, Dombernowsky P (1991) Dose limiting hypotension with the 5-HT3 antagonist batanopride (BMY-25801). Ann Oncol 2:154–155

    Google Scholar 

  10. Herrstedt J, Sigsgaard T, Boesgaard M, Jensen TP, Dombernowsky P (1993) Ondansetron plus metopimazine compared with ondansetron alone in patients receiving moderately emetogenic chemotherapy. N Engl J Med 328:1076–1080

    Google Scholar 

  11. Kobrinsky NL (1988) Regulation of nausea and vomiting in cancer chemotherapy. Am J Pediatr Hematol Oncol 10:209–213

    Google Scholar 

  12. Kobrinsky NL, Pruden PB, Cheang MS, et al (1988) Increased nausea and vomiting induced by naloxone in patients receiving cancer chemotherapy. Am J Pediatr Hematol Oncol 10:206–208

    Google Scholar 

  13. Lang IM, Sarna SK (1992) The role of adrenergic receptors in the initiation of vomiting and its gastrointestinal motor correlates. J Pharmacol Exp Ther 263:395–403

    Google Scholar 

  14. Moertel CG, Reitemeier RJ, Gage RP (1963) A controlled clinical evaluation of antiemetic drugs. JAMA 186:116–118

    Google Scholar 

  15. Navari RM, Plezia P, Kaplan HG, Gralla RJ, Grunberg SM (1993) Single-dose, double-blind, multicenter study evaluating the efficacy and safety of intravenous granisetron in the prevention of cisplatin-induced nausea and vomiting. Proc ASCO 12:438

    Google Scholar 

  16. Nelson KA, Walsh D, Sheehan FA (1994) The cancer anorexia cachexia syndrome. J Clin Oncol 12:213–225

    Google Scholar 

  17. Palacios JM, Wamsley JK, Kuhar MJ (1981) The distribution of histamine H1-receptors in the rat brain: an autoradiographic study. Neuroscience 6:15–37

    Google Scholar 

  18. Roila F, Tonato M, Cognetti F, et al (1991) Prevention of cisplatin-induced emesis: a double-blind multicenter randomized crossover study comparing ondansetron and ondansetron plus dexamethasone. J Clin Oncol 9:675–678

    Google Scholar 

  19. Silvey L, Carpenter JT Jr, Wheeler RH, Lee J, Conolley C (1988) A randomized comparison of haloperidol plus dexamethasone versus prochlorperazine plus dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for breast cancer. J Clin Oncol 6:1397–1400

    Google Scholar 

  20. Van Hazel GA, Frytak S, Anderson SA, O'Fallon JR, Moertel CG, Long HJ (1983) A double-blind randomized crossover study comparing high-dose metoclopramide to dexamethasone + prochlorperazine as antiemetics during cisplatin chemotherapy. Proc ASCO 2:85

    Google Scholar 

  21. Van Wijngaarden I, Tulp MThM, Soudijn W (1990) The concept of selectivity in 5-HT research. Eur J Pharmacol 188:301–312

    Google Scholar 

  22. Wamsley JK, Lewis MS, Young WS III, Kuhar MJ (1981) Autoradiographic localization of muscarinic cholinergic receptors in rat brainstem. J Neurosci 1:176–191

    Google Scholar 

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  1. Vermont Cancer Center, 1 South Prospect Street, 05401, Burlington, VT, USA

    Steven M. Grunberg M. D.

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  1. Steven M. Grunberg M. D.
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Grunberg, S.M. Future of the management of emesis. Support Care Cancer 2, 301–303 (1994). https://doi.org/10.1007/BF00365582

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