Riassunto
Questo lavoro rappresenta la continuazione delle comunicazioni preliminari sulla resistenza insulinica dei nati di madri insulino-resistenti. Le ricerche sono state condotte su cavie e su uomini. E' stato dimostrato che gli anticorpi anti-insulina passano nel circolo fetale inducendovi la comparsa di una insulino-resistenza passiva che scompare nelle prime settimane di vita. Gli anticorpi contro l'insulina bovina legano in parte l'insulina endogena di cavie, come è evidenziato dall'elevata iperglicemia delle cavie giovani nate da madri insulino-resistenti. Gli anticorpi anti-insulina non esercitano alcun effetto di rilievo sulla struttura del pancreas delle cavie nel periodo perinatale.
Resume
Ce travail est la continuation des communications préliminaires sur la résistance insulinique des nouveaux-nés de mères insuline-résistantes. Les recherches ont été conduites sur cobayes et sur sujets humains. Les AA. ont démontré que les anticorps anti-insuline passent dans la circulation fœtale et provoquent l'apparition d'une insuline-résistance passive qui va disparaître dans les premières semaines de la vie. Les anticorps contre l'insuline bovine lient en partie l'insuline endogène des cobayes, ce qui est mis en evidence par l'hyperglycémie élevée des cobayes jeunes nées de mères insuline-résistantes. Les anticorps anti-insuline n'ont aucun effet important sur la structure du pancréas des cobayes dans la période périnatale.
Resumen
Este trabajo representa la continuación de las comunicaciones preliminares sobre la resistencia insulínica que presentan las personas nacidas de madres insulino-resistentes. Las investigaciones han sido efectuadas en cobayas y hombres. Se ha demostrado que los anticuerpos anti-insulina pasan al círculo fetal, provocando la aparición de insulino-resistencia pasiva, que desaparece durante las primeras semanas de vida. Los anticuerpos contra la insulina bovina ligan en parte la insulina endógena de cobayas, como lo demuestra la hiperglucemia elevada de las cobayas jóvenes nacidas de madres insulino-resistentes. Los anticuerpos anti-insulina no ejercen ningún efecto apreciable sobre la estructura del páncreas de las cobayas durante el período peri-natal.
Zusammenfassung
Diese Arbeit stellt die Fortsetzung der vorlaeufigen Mitteilungen ueber die Insulinresistenz bei Kindern insulin-resistenter Muetter dar. Die Untersuchungen wurden bei Meerschweinchen und Menschen durchgefuehrt. Es wurde nachgewiesen, dass die Insulin-Antikoerper in den foetalen Kreislauf uebergehen und das Auftreten einer passiven Insulin-Resistenz induzieren, die in den ersten Lebenswochen verschwindet. Die Antikoerper gegen Rinderinsulin binden zum Teil das endogene Meerschweinchen-Insulin, wie aus der ausgepraegten Hyperglykaemie von jungen Meerschweinchen insulin-resistenter Muttertiere hervorgeht. Die Insulin-Antikoerper ueben keine nennenswerte Wirkung auf die Pankreasstruktur der Meerschweinchen in der perinatalen Periode aus.
Summary
This paper continues the preliminary communications on the insulin resistance of the offspring of insulin-resistant mothers. The investigations were carried out in guinea pigs and humans. It was shown that insulin antibodies pass into the fetal circulation which results in the appearance of passive insulin-resistance. This resistance disappears in the first weeks of life. Antibodies to bovine insulin bind in part endogenous insulin of guinea pigs, as demonstrated by marked hyperglycemia in the offspring of insulin-resistant mothers. Insulin antibodies have no noticeable effect on the architecture of the pancreas in guinea pigs in the perinatal period.
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This work was subsidized in part by the Polish Academy of Science.
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Starzyńska, R., Seniow, S., Kodejszko, E. et al. Studies on the transport of insulin antibodies across the placenta to the fetus and their effect on the fetal pancreatic islet system. Acta diabet. lat 6, 573–584 (1969). https://doi.org/10.1007/BF01548073
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DOI: https://doi.org/10.1007/BF01548073