Abstract
The in vitro activity of the new lipopeptide antibiotic LY146032 was generally four-fold greater (MIC 90 ⩽ 0. 5μg/ml) than that of vancomycin against methicillin-susceptible or methicillin-resistantStaphybcoccus aureus and coagulase-negative species ofStaphylococcus. Enterococci,Streptococcus bovis, group B and viridans streptococci, andCorynebacterium group J-K isolates were inhibited by ≤ 4μg/ml of LY146032, which represented activity equivalent to or greater than that of vancomycin. Unlike vancomycin, LY146032 was bactericidal forEnterococcus faecalis, Enterococcus faecium andListeria monocytogenes. Due to its bactericidal properties LY146032 appeared to represent an improvement over vancomycin and teicoplanin.
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References
National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved Standard M7-A. Villanova, PA, 1985.
Thornsberry, C., McDougal, L. K.: Successful use of broth microdilution in susceptibility tests for methicillinresistant (heteroresistant) staphylococci. Journal of Clinical Microbiology 1983, 18: 1084–1091.
Pearson, R. P., Steigbigel, R. T., Davis, H. T., Chapman, S. W.: Method for reliable determination of minimal lethal antibiotic concentrations. Antimicrobial Agents and Chemotherapy 1980, 18: 699–708.
Haley, R. W., Hightower, A. W., Khabbaz, R. F., Thomsberry, C., Martone, W. J., Allen, J. R., Hughes, J. M.: The emergence of methicillin-resistantStaphylococcus aureus infections in United States Hospitals. Annals of Internal Medicine 1982, 97: 297–308.
Karchmer, A. W., Archer, G. L., Dismukes, W. E.:Staphylococcus epidermidis causing prosthetic valve endocarditis: microbiologic and clinical observations as guides to therapy. Annals of Internal Medicine 1983, 98: 447–455.
Young, V. M., Meyers, W. F., Moody, M. R., Schimpff, S. C.: The emergence of coryneform bacteria as a cause of nosocomial infections in compromised hosts. American Journal of Medicine 1981, 70: 646–650.
Riley, P. S., Hollis, D. G., Utter, G. B., Weaver, R. E., Baker, C. N.: Characterization and identification of 95 diphtheroid (group JK) cultures isolated from clinical specimens. Journal of Clinical Microbiology 1979, 9: 418–424.
Watanakunakorn, C.: Treatment of infections due to methicillin-resistantStaphylococcus aureus. Annals of Internal Medicine 1979, 97: 376–378.
Shanson, D. C., Tadayon, M.: Activity of teicoplanin compared with vancomycin alone, and combined with gentamicin, against penicillin tolerant viridans streptococci and enterococci causing endocarditis. Journal of Hospital Infection 1986, 7, Supplement A: 65–72.
Watanakunakorn, C., Bakie, C.: Synergism of vancomycin-gentamicin and vancomycin-streptomycin against enterococci. Antimicrobial Agents and Chemotherapy 1973, 4: 120–124.
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Jorgensen, J.H., Maher, L.A. & Redding, J.S. In vitro activity of LY146032 (Daptomycin) against selected aerobic bacteria. Eur. J, Clin. Microbiol. 6, 91–96 (1987). https://doi.org/10.1007/BF02097209
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DOI: https://doi.org/10.1007/BF02097209