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Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results

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Abstract

The interim results of a multicentered clinical trial with the combination therapy Pilogel®/topical β-blocker (twice daily) in patients with primary open angle glaucoma or ocular hypertension are discussed. Six patients were treated with Pilogel® and a topical β-blocker for one month. Four out of six patients responded well to the combination therapy. Most patients experienced some difficulty in applying the gel and their eyelids stuck together on awakening. In two patients a superficial punctate keratitis was observed. We found an average decrease in intra-ocular pressure (IOP) of 22.5% 22.5 hours after Pilogel® administration, but there was some tendency towards higher evening values compared to morning values. In view of the appearance of a corneal haze as described by Johnson et al. during long-term treatment, longer follow-up is necessary.

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Authors and Affiliations

  1. Department of Ophthalmology, Diakonessenhuis Utrecht, Utrecht, The Netherlands

    S. Maas & F. E. Ros

  2. Eye Hospital, Rotterdam, The Netherlands

    LJ. de Heer

  3. Department of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands

    R. J. W. De Keizer

Authors
  1. S. Maas
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  2. F. E. Ros
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  3. LJ. de Heer
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  4. R. J. W. De Keizer
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Maas, S., Ros, F.E., de Heer, L. et al. Efficacy and safety of the combination therapy Pilogel®/β-blocker: Interim results. Doc Ophthalmol 72, 391–398 (1989). https://doi.org/10.1007/BF00153508

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  • DOI: https://doi.org/10.1007/BF00153508

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