Summary
Children with pyogenic peritonitis following appendicits produce antibodies against the common enterobacterial antigen (CA) in unusually high titers when compared to patients with salmonellosis, shigellosis, or urinary tract infection. The duration of this antibody response was determined in 19 children observed over a period of up to 31 months after the acute illness. CA antibody titers decreased significantly in 70% of the patients during the first year and in 91% of those studied between 13 and 31 months after the infection. In the majority (71%) of patients the antibody titers returned to pre-or near pre-infection levels within 31 months after the acute illness. Only in a few patients (19%) were near maximal titers maintained during the observation period. The titers of anti-bodies against the O antigens of the infecting microorganisms also decreased in the majority of subjects during the follow-up period of observation. These findings may be of importance in connection with studies on the immune response of patients with urinary tract and other infections.
Zusammenfassung
Kinder mit eitriger Peritonitis bei vorausgehender Appendizitis produzieren Antikörper gegen das gemeinsame enterobakterielle Antigen (CA) in ungewöhnlich hohen Titern im Vergleich mit Patienten mit Salmonellosis, Shigellosis oder Infektionen der Harnwege. Die Dauer dieser Antikörperproduktion wurde bei 19 Kindern festgestellt, welche in einem Zeitraum bis zu 31 Monaten nach der akuten Krankheit beobachtet wurden. Die Titer der CA Antikörper gingen in 70% der Patienten im 1. Jahr und in 91% derselben zwischen 13 und 31 Monaten nach der Infektion stark zurück. Bei der Mehrzahl (71%) der Patienten gingen die Antikörpertiter innerhalb von 31 Monaten nach der akuten Krankheit auf die ursprünglichen Werte zurück. Nur bei einigen Patienten (19%) blieben die maximalen Titer während der Beobachtungszeit fast unverändert. Die Antikörpertiter gegen die O Antigene der infizierenden Mikroorganismen verminderten sich ebenso in der Mehrzahl der Kinder. Diese Ergebnisse mögen in der Verbindung mit den Studien der Antikörperproduktion von Patienten mit Infektionen der Harnwege und anderen Infektionen von Wichtigkeit sein.
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Literature
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Griffiths, E., Jewett, T. & Neter, E. Duration of antibody responses to common enterobacterial and O antigens of children with pyogenic peritonitis. Infection 4, 1–4 (1976). https://doi.org/10.1007/BF01638339
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DOI: https://doi.org/10.1007/BF01638339