Summary
Cefadroxil, a new semi-synthetic broad-spectrum cephalosporin, was administered to 144 patients with acute (64.6%) and chronic (35.4%) urinary tract infections. An excellent correlation was found between clinical response (cured+improved=82.6%) and bacteriological eradication of the causative organism (88.9%). The drug was very well tolerated, even after prolonged administration (up to 23 days): side-effects only appeared in 6 cases (=4.2%), two of which were rashes (=1.4%). In one of the participating laboratories, 22 (=35%) of the pre-treatment isolated strains were found to be resistant to ampicillin or derivatives: all of these 22 strains proved to be sensitive towards cefadroxil.
Zusammenfassung
Cefadroxil, ein neues, halbsynthetisches Breitspektrum-cephalosporin wurde 144 Patienten mit akuten (64,6%) und chronischen (35,4%) Harnwegsinfektionen verabreicht. Eine hervorragende Korrelation bestand zwischen klinischem Ansprechen (geheilt+gebessert=82,6%) und der Elimination der verantwortlichen Erreger (88,9%). Das Medikament wurde sehr gut vertragen, auch nach Langzeitanwendung (bis zu 23 Tagen): Nebenwirkungen traten nur bei sechs Fällen auf (4,2%), zwei davon waren Exantheme (1,4%). In einem der beteiligten Laboratorien wurde festgestellt, daß 22 (35%) der vor der Behandlung isolierten Stämme gegen Ampicillin oder seine Derivate resistent waren: alle diese 22 Stämme zeigten sich gegenüber Cefadroxil sensibel.
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Erstveröffentlichung: Drugs Exptl. clin. Res. 4 (1978) 95.
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Reynaert, J., Vandepitte, J., Desmet, R. et al. Clinical evaluation of cefadroxil: A multicenter trial. II. Urinary tract infections. Infection 8 (Suppl 5), S617–S622 (1980). https://doi.org/10.1007/BF01639682
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DOI: https://doi.org/10.1007/BF01639682