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Ultrasound measurements on os calcis: Precision and age-related changes in a normal female population

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Abstract

We performed ultrasound measurements in the calcaneus of 512 healthy women. Broadband ultrasonic attenuation (BUA) and speed of sound (SOS) were obtained with a Lunar Achilles ultrasonic instrument. Subjects studied were one group of 67 women working in our hospital (group A) and two groups which are part of two large prospective cohort studies (groups B and C). Group B consisted of 244 women aged 31–79 years randomly selected from a large insurance company, and group C consisted of 201 women aged 74–91 years randomly selected from the electoral rolls. Dual-energy X-ray absorptiometry (DXA) measurements of femoral neck and total body were performed with a Hologic QDR 2000 for group B and with a Lunar DPX Plus for group C. The in vitro precision of the Achilles, estimated by measuring a phantom daily for 45 days, was 0.84% for BUA and 0.12% for SOS. We assessed the in vivo short-term precision in 20 healthy volunteers working at the hospital, measured three times each. The coefficients of variation were 0.93% (±0.21) for BUA and 0.15% (±0.03) for SOS. The precision error was compared with the true variation, to obtain a standardized coefficient of variation. We analysed the three groups pooled together (n=512) and found for BUA an average 20% decrease and for SOS a 5% decrease between the ages of 20 and 90 years. We also performed separate analyses of subjects younger than 50 and older than 50 years, and within each 10-year age group we found that BUA was stable or slightly increased from 20 to 50 years and then decreased after 50. In contrast, SOS did not increase but decreased from the age of 20. We compared DXA measurements of the femoral neck and the total body with ultrasound measurements in groups B and C. In both groups the correlations were better with total body DXA than with femoral neck and spine DXA.

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References

  1. Cummings SR, Black DM, Nevitt MC Browner WS, et al. Appendicular bone density and age predict hip fracture in women. JAMA 1990;263:665–8.

    Google Scholar 

  2. Langton CM, Palmer SB, Porter RW. The measurement of broadband ultrasonic attenuation in cancellous bone. Eng Med 1984;13:89–91.

    Google Scholar 

  3. Biot MA. Generalized theory of acoustic propagation in porous dissipative media. J Acoust Soc Am 1962;34:1254–64.

    Google Scholar 

  4. Jones PRM, Langton CM, Carr H. Broadband ultrasonic attenuation studies in sedentary and active young male adults and in bovine cancellous and cortical bone. IOP short meetings series no. 6. London: Institute of Physics, 1987:37–45.

    Google Scholar 

  5. Langton CM, Evans GP, Hodgskinson R, Riggs CM. Ultrasonic, elastic and structural properties of cancellous bone. AJR 1990.

  6. Eastell R. Bone density of the calcaneus measured by ultrasound and DXA. In: Private symposium on ultrasound for bone measurement, Florence, April 1992.

  7. McCloskey EV, Murray SA, Charlesworth D, Miller C, Fordham J, Clifford K, Atkins R, Kanis JA. Assessment of broadband ultrasound attenuation in the os calcis in vitro. Clin Sci 1990;78:221–5.

    Google Scholar 

  8. Mazess RB, Trempe J, Genske T, Wiener S. Ultrasound measurements of the os calcis. In: Private symposium on ultrasound for bone measurement, Florence, April 1992.

  9. Lees B, Stevenson JC. Preliminary evaluation of new ultrasound bone densitometer. In: Bone and Tooth Society, spring meeting, 23 March 1992, p. 9.

  10. Heaney RP, Avioli LV, Chestnut III CH, Lappe J, et al. Osteoporotic bone fragility: detection by ultrasound transmission velocity. JAMA 1989;261:2986–90.

    Google Scholar 

  11. Antich P, Pak CYC, Gonzales J, Anderson J, Sakhaee K, Rubin C. Measurement of bone strength in vivo by reflection ultrasound: effect of aging, osteoporotic development and treatment with slow-release sodium fluoride. J Bone Miner Res 1991;6 (Suppl):358.

    Google Scholar 

  12. Langton CM, Evans GP. Dependence of ultrasonic velocity and attenuation on the material properties of cancellous bone [abstract]. Osteoporosis Int 1991;1:194.

    Google Scholar 

  13. Brandenburger G, Waud K, Baran D. Reproducibility of uncorrected velocity of sound does not indicate true precision. J Bone Miner Res 1992;7 (Suppl):368.

    Google Scholar 

  14. Miller CG, Herd RJM, Ramaligham T, Fogelman I, Blake GM. Ultrasonic velocity measurements through the calcaneus: which velocity should be measured? Osteoporosis Int 1993 (in press).

  15. Waud CE, Lew R, Baran D. Broadband ultrasound attenuation of the calcaneus correlates with density of the calcaneus: potential radiation free technique to assess fracture risk. J. Bone Miner Res 1991;6 (Suppl):349

    Google Scholar 

  16. Mazess RB, Hanson JA, Bonnick SL. Ultrasound measurement of the os calcis. In: Symposium of the British Bone and Tooth Society, 23–24 September 1991.

  17. Eastell R, Naylor KE, Abdulrahmen A, Smith TWD, Langton CM. Comparison of ultrasound with DEXA. In: Ultrasonic assessment of osteoporosis and bone development: an expert workshop, Cologne, 5–6 March 1992.

  18. Agren M, Karellas A, Leahey D, Marks S, Baran D. Ultrasound attenuation of the calcaneus: a sensitive and specific discriminator of osteopenia in postmenopausal women. Calcif Tissue Int 1991;48:240–4.

    Google Scholar 

  19. Reid DM, Massie A, Porter RW. Bone mineral density and structure: comparison of hip and spine dual energy X-ray absorptiometry with broadband ultrasound attenuation for osteoporosis screening [abstract]. Osteoporosis Int 1991;1:194.

    Google Scholar 

  20. Naylor KE, Langton CM, Smith TWD, Eastell R. Broadband ultrasound attenuation of the calcaneus: relationship to bone mineral density measured by dual energy X-ray absorptiometry at several sites. J Bone Miner Res 1991;6 (Suppl):350.

    Google Scholar 

  21. Parfitt AM, Matthews CHE, Villaneuva AR, Kleerekoper M, Frame B, Rao DS. Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis: implications for the microanatomic and cellular mechanisms of bone loss. J. Clin Invest 1983;72:1396–409.

    Google Scholar 

  22. Porter RW, Miller CG, Grainger D, Palmer SB. Prediction of hip fracture in elderly women: a prospective study. BMJ 1990;638-41.

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Authors and Affiliations

  1. INSERM Unit 234, Epidemiology Section, Pavilion F, Hôpital Edouard Herriot, 69437, Lyon Cedex 03, France

    A. M. Schott, D. Hans, E. Sornay-Rendu, P. D. Delmas & P. J. Meunier

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  1. A. M. Schott
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  2. D. Hans
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  3. E. Sornay-Rendu
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  4. P. D. Delmas
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  5. P. J. Meunier
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Schott, A.M., Hans, D., Sornay-Rendu, E. et al. Ultrasound measurements on os calcis: Precision and age-related changes in a normal female population. Osteoporosis Int 3, 249–254 (1993). https://doi.org/10.1007/BF01623828

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  • DOI: https://doi.org/10.1007/BF01623828

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