Abstract
Knowledge of selective muscle-involvement is useful to the clinician. Therefore we investigated in sarcoglycanopathy and dysferlinopathy: (i) the correlation between clinical scale, MRC scale and CT findings and (ii) the muscles involved. Patients with a definite diagnosis of dysferlinopathy and sacroglycanopathy were tested for their clinical functions and muscle strength and assigned a functional grade. Nineteen muscles were evaluated by CT. In dysferlinopathy, distal lower-limb muscles are involved, while in sarcoglycanopathy proximal muscles are more affected. In both groups, muscles with MRC <3 often had severe abnormalities on CT imaging, while muscles with MRC >4 could be either normal or abnormal. Dysferlinopathy and sarcoglycanopathy have different and selective muscle involvement. This may affect certain types of functional activity. There is a possible relationship between CT findings and MRC grade in muscles with a low (<3) MRC grade. Abnormality on CT scan may precede the clinical symptoms.
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Vlak, M., van der Kooi, E. & Angelini, C. Correlation of clinical function and muscle CT scan images in limb-girdle muscular dystrophy. Neurol Sci 21 (Suppl 3), S975–S977 (2000). https://doi.org/10.1007/s100720070013
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DOI: https://doi.org/10.1007/s100720070013