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Untersuchungen zur Pathogenese der aktiven chronischen Hepatitis

Investigations on the pathogenesis of active chronic hepatitis

  • Published:
Zeitschrift für die gesamte experimentelle Medizin einschließlich experimentelle Chirurgie

Summary

The immune response towards native and altered homologous and heterologous liver specific protein was examined in the rabbit. Immunization with serumproteins and antigen-antibody-complexes served as controlls. The immunological tolerance for soluble liver specific protein can be destroyed with altered homologous or heterologous proteins. Organ-specific autoantibodies and specifically sensitized cells could be found after a 2–3 months immunization-period with chemically altered protein and after 6 months when heterologous proteins were used. Active chronic hepatitis could be detected after a long-term (7–8 months) immunization with small doses of antigen together with evidence for a delayed typ hypersensitivity-reaction. Large doses of antigen and their application for short periods are followed by sensitivity reactions, which do not depend on the antigen used.

Zusammenfassung

Es wird über die Ergebnisse von Sensibilisierungen bei Kaninchen mit nativen und alterierten homologen sowie heterologen organgebundenen Leberproteinen, Serumproteinen und Antigen-Antikörper-Komplexen berichtet. — Die neonatal erworbene Immuntoleranz gegenüber löslichem organgebundenem Leberprotein ist mit alteriertem homologem oder heterologem Protein zerstörbar. Organspezifische Autoantikörper bzw. spezifisch-sensibilisierte Zellen konnten bei Verwendung von haptenisierten homologen Proteinen nach 2–3 Monaten, bei Verwendung von heterologen Proteinen nach 6 Monaten nachgewiesen werden. — Der Befund einer aktiven chronischen Hepatitis fand sich nach langdauernder Sensibilisierung mit kleinen Antigendosen (7–8 Monate) und Entwicklung einer Hypersensibilität vom verzögerten Typ. Die massive Stimulierung einer Autoantikörperbildung in einem kürzeren Zeitraum führt dagegen nur zu einer — von der Art des Antigens unabhängigen — Sensibilisierungsreaktion.

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Authors and Affiliations

  1. Pathologisches Institut und II. Medizinische Klinik, Johannes Gutenberg-Universität Mainz, Deutschland

    F. K. Kössling & K. H. Meyer zum Büschenfelde

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  1. F. K. Kössling
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  2. K. H. Meyer zum Büschenfelde
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Herrn Professor Dr. Schopper zum 70. Geburtstag gewidmet.

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Kössling, F.K., Meyer zum Büschenfelde, K.H. Untersuchungen zur Pathogenese der aktiven chronischen Hepatitis. Z. Gesamte Exp. Med. 153, 150–161 (1970). https://doi.org/10.1007/BF02044688

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  • DOI: https://doi.org/10.1007/BF02044688

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