Skip to main content
SpringerLink
Log in

A model-independent comparison of the rates of uptake and short term retention of47Ca and85Sr by the skeleton

  • Original Papers
  • Published:
Calcified Tissue Research Aims and scope Submit manuscript

Abstract

  1. 1.

    A method has been devised for comparing the impulse response functions of the skeleton for two or more boneseeking tracers, and for estimating the contribution made by measurement errors to the differences between any pair of impulse response functions.

  2. 2.

    Comparisons were made between the calculated impulse response functions for47Ca and85Sr obtained in simultaneous double tracer studies in sixteen subjects. Collectively the differences between the47Ca and85Sr functions could be accounted for entirely by measurement errors.

  3. 3.

    Because the calculation of an impulse response function requires fewera priori assumptions than other forms of mathematical analysis, and automatically corrects for differences induced by recycling of tracer and non-identical rates of excretory plasma clearance of tracer, it is concluded that differences shown in previous in vivo studies between the fluxes of*Ca and*Sr into bone can be fully accounted for by undetermined oversimplifications in the various mathematical models used to analyse the results of those studies.85Sr is therefore an adequate tracer for bone calcium in most in vivo studies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bishop, M., Harrison, G. E., Raymond, W. H. A., Sutton, S., Rundo, J.: Excretion and retention of radioactive strontium in normal men following a single intravenous injection. Int. J. Radiat. Biol.2, 125–142 (1960)

    PubMed  Google Scholar 

  2. Bronner, F., Aubert, J-P., Richelle, L. J., Saville, P. D., Nicholas, J. A., Cobb, J. R.: Strontium and its relation to calcium metabolism. J. clin. Invest.42, 1095–1104 (1963)

    PubMed  Google Scholar 

  3. Carr, T. E. F., Harrison, G. E., Nolan, J.: The long term excretion and retention of an intravenous dose of45Ca in two healthy men. Calcif. Tiss. Res.12, 217–226 (1973)

    Article  Google Scholar 

  4. Cohn, S. H., Lippincott, S. W., Gusmano, E. A., Robertson, J. S.: Comparative kinetics of47Ca and85Sr in man. Radiat. Res.19, 104–119 (1963)

    PubMed  Google Scholar 

  5. Dow, E. C., Stanbury, J. B.: Strontium and calcium metabolism in metabolic bone disease. J. clin. Invest.39, 885–903 (1960)

    PubMed  Google Scholar 

  6. Marshall, J. H.: Measurements and models of skeletal metabolism. In: Mineral metabolism, Ch. 1, pp. 1–122, Eds. C. L. Comar and F. Bronner. New York: Academic Press

  7. Marshall, J. H., Liniecki, J., Lloyd, E. L., Marotti, G., Mays, C. W., Rundo, J., Sissons, H. A., Snyder, W. S.: Alkaline earth metabolism in adult man. Hlth Phys.24, 125–221 (1973)

    Google Scholar 

  8. Reeve, J., Wootton, R., Hesp, R.: A new method for calculating the accretion rate of bone calcium and some observations on the suitability of strontium-85 as a tracer for bone calcium. Calcif. Tiss. Res. (In press)

  9. Rösick, U., Zimen, K. E.: Diffusion von45Ca,85Sr und32P in hydroxylapatit. Biophysik9, 120–131 (1973)

    Article  PubMed  Google Scholar 

  10. Shimmins, J., Smith, D. A., Nordin, B. E. C., Burkinshaw, L.: A comparison between Calcium-45 and Strontium-85, absorption, excretion and skeletal uptake. Strontium Metabolism, p. 149, Eds. J. M. Leniham, J. F. Loutit and J. H. Martin. London: Academic Press 1967

    Google Scholar 

  11. Veall, N.: Statistical factors affecting radioactivity measurements. In: Radioisotopes in medical diagnosis, Ch. 4, pp. 64–78, Eds. E. H. Belcher and H. Vetter. London: Butterworths

Download references

Author information

Authors and Affiliations

  1. Radioisotopes Division, Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK

    J. Reeve & R. Hesp

Authors
  1. J. Reeve
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Hesp
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reeve, J., Hesp, R. A model-independent comparison of the rates of uptake and short term retention of47Ca and85Sr by the skeleton. Calc. Tis Res. 22, 183–189 (1977). https://doi.org/10.1007/BF02010357

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02010357

Key words

Search

Navigation