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Effects of intravenous vitamin D on bone and phosphate metabolism in osteomalacia

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Abstract

The effect of a 1 mg dose of intravenous Vitamin D3 (40,000 i.u.) on bone histology and phosphate metabolism was investigated in 19 patients with normal bone histology and 28 patients with histological evidence of osteomalacia. No significant changes occurred in the control patients after Vitamin D but the patients with osteomalacia showed a marked increase, within seven days, in the proportion of osteoid having a calcification front. This was accompanied by a progressive rise in the serum phosphate, which was associated with an increase in the renal tubular reabsorption of phosphate to normal.

Résumé

Les effects d'une dose de 1 mg de vitamine D3 (40 000 Unités,) administrée par voie intra-veineuse, ont été étudiés sur l'histologie osseuse et le métabolisme du phosphore chez 19 sujets contrôles dont l'histologie était normale et 28 malades présentant les caractères histologiques de l'ostéomalacie par carence vitaminique D.

L'administration de la vitamine D n'a entraîné aucune modification histologique ou biologique significative chez les sujets contrôles. Mais chez les ostéomalaciques, il est apparu en moins de sept jours une augmentation très significative du front de calcification à l'interface tissue-ostéoïde-tissue-calcifié. Cette modification s'accompagnait d'une ascension progressive de la phosphatémie et de la réabsorption tubulaire du phosphore atteignant dans le même délai des valeurs normales.

Zusammenfassung

Bei 19 Patienten mit normaler Knochenhistologie und bei 28 Patienten mit histologisch gesicherter Osteomalacie wurde die Wirkung von 1 mg Vitamin D3 (40000 Iv) i.v. auf die Knochenhistologie und den Phosphatmetabolismus untersucht. Bei den Kontrollpatienten konnten keine signifikanten Änderungen nach Vitamin D festgestellt werden, wogegen die Osteomalacie-patienten innerhalb von 7 Tagen eine deutliche Zunahme der Verkalkungszone an der Grenze zwischen Osteoid- und Knochengewebe zeigten. Diese Änderung war von einer fortschreitenden Zunahme des Serum-Phosphates, verbunden mit einer gesteigerten renalen tubulären Rückabsorption des Phosphates begleitet; beide kehrten anschließend gleichzeitig wieder zur Norm zurück.

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Authors and Affiliations

  1. Unité de Recherche sur le Métabolisme Phosphocalcique (I.N.S.E.R.M.), Hôpital Lariboisière, 10e, Paris, France

    Ph. Bordier, D. Hioco & M. Rouquier

  2. Department of Medicine, Royal Postgraduate Medical School, Ducane Road, W. 12, London

    G. W. Hepner & G. R. Thompson

Authors
  1. Ph. Bordier
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  2. D. Hioco
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  3. M. Rouquier
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  4. G. W. Hepner
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  5. G. R. Thompson
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Bordier, P., Hioco, D., Rouquier, M. et al. Effects of intravenous vitamin D on bone and phosphate metabolism in osteomalacia. Calc. Tis Res. 4, 78–83 (1969). https://doi.org/10.1007/BF02279108

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  • DOI: https://doi.org/10.1007/BF02279108

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