Effects of low-dose dobutamine on left ventricular diastolic filling in children

Abstract

To investigate the effects of dobutamine on the Doppler transmitral flow pattern in children with normal left ventricular function, Doppler echocardiography was used to measure the transmitral flow in 14 healthy children before and during infusion of dobutamine (5 μg/kg per minute). Cardiac output was measured by the thermodilution method, and stroke volume was calculated as the cardiac output divided by the heart rate. Dobutamine increased the peak velocity and flow velocity-time integral of early diastolic filling without changing those of atrial contraction and normalized peak velocity of early diastolic filling, suggesting an increase in left ventricular relaxation. Dobutamine increased the stroke volume and rate-corrected mean velocity of fiber shortening with reduced end-systolic wall stress, indicating an increase in left ventricular contractility. The percentage of increase in the flow velocity-time integral of early diastolic filling during dobutamine infusion tended to correlate with the increase in stroke volume (r=0.67,p<0.05) and with the decrease in end-systolic wall stress (r=−0.61,p<0.05). Our results suggest that low-dose dobutamine increases left ventricular relaxation with enhanced systolic function. The observed decreased end-systolic wall stress might have caused enhanced relaxation characteristics with dobutamine.