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Modelling autonomous oscillations in the human pupil light reflex using non-linear delay-differential equations

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Abstract

Neurophysiological and anatomical observations are used to derive a non-linear delay-differential equation for the pupil light reflex with negative feedback. As the gain or the time delay in the reflex is increased, a supercritical Hopf bifurcation occurs from a stable fixed point to a stable limit cycle oscillation in pupil area. A Hopf bifurcation analysis is used to determine the conditions for instability and the period and amplitude of these oscillations. The more complex waveforms typical of the occurrence of higher order bifurcations were not seen in numerical simulations of the model. This model provides a general framework to study the different types of dynamical behaviors which can be produced by the pupil light reflex, e.g. edge-light pupil cycling.

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Authors and Affiliations

  1. Dept of Physics, McGill University, H3G 1Y6, Montreal, Canada

    André Longtin

  2. Dept of Physiology, McGill University, H3G 1Y6, Montreal, Canada

    John G. Milton

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  1. André Longtin
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Longtin, A., Milton, J.G. Modelling autonomous oscillations in the human pupil light reflex using non-linear delay-differential equations. Bltn Mathcal Biology 51, 605–624 (1989). https://doi.org/10.1007/BF02459969

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  • DOI: https://doi.org/10.1007/BF02459969

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