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Lack of platelet response to collagen associated with autoantibodies against glycoprotein (GP) Ia/IIa and Ib/IX leading to the discovery of SLE

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Hematology and Cell Therapy

Abstract

An increased bleeding time and a prolonged APTT (activated partial thromboplastin time) observed in a 48-year-old woman led to the discovery of SLE confirmed by immunological tests. Platelet function and analysis of membrane glycoproteins revealed an isolated impaired collagen induced platelet aggregation and allowed the detection of autoantibodies directed against GpIa/IIa and GpIb/IX.

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Authors and Affiliations

  1. Laboratoire d’Hématologie, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, F-75743, Paris Cedex 15, France

    A. Dromigny & P. Triadou

  2. Département de Néphrologie, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, F-75743, Paris Cedex 15, France

    P. Lesavre

  3. Service d’Immunologie Leucoplaquettaire, Institut National de Transfusion Sanguine, 6, rue Alexandre Cabanel, F-75015, Paris, France

    M. C. Morel-Kopp & C. Kaplan

Authors
  1. A. Dromigny
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  2. P. Triadou
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  3. P. Lesavre
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  4. M. C. Morel-Kopp
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  5. C. Kaplan
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Dromigny, A., Triadou, P., Lesavre, P. et al. Lack of platelet response to collagen associated with autoantibodies against glycoprotein (GP) Ia/IIa and Ib/IX leading to the discovery of SLE. Hematol Cell Ther 38, 355–357 (1996). https://doi.org/10.1007/s00282-996-0355-7

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  • DOI: https://doi.org/10.1007/s00282-996-0355-7

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