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Synergistic effect of K-18 and concomitant hyperthermia for treatment of lewis lung carcinoma in mice

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Abstract

We investigated the synergistic anti-tumor effects of K-18 (conjugate of human γ-globulin and melphalan) and concomitantly administered hyperthermia on Lewis lung carcinoma in mice. The antitumor effect of a subeffective dose of K-18 or an equivalent dose of melphalan alone was enhanced by local hyperthermia. K-18 administration demonstrated a greater potentiation for inhibition of tumor growth than that of melphalan alone. Local hyperthermia plus K-18 reduced the dose of melphalan required for tumor growth inhibition by melphalan alone. The combined application of K-18 and hyperthermia for treating cancer warrants further study.

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Authors and Affiliations

  1. The Second Department of Surgery, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, 812, Fukuoka, Japan

    Ryuichiro Tamada, Hideaki Kai, Keizo Sugimachi, Kenji Takenaka, Yoichiro Hiramoto & Kiyoshi Inokuchi

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  1. Ryuichiro Tamada
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  2. Hideaki Kai
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  3. Keizo Sugimachi
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  4. Kenji Takenaka
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  5. Yoichiro Hiramoto
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  6. Kiyoshi Inokuchi
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Tamada, R., Kai, H., Sugimachi, K. et al. Synergistic effect of K-18 and concomitant hyperthermia for treatment of lewis lung carcinoma in mice. The Japanese Journal of Surgery 15, 173–176 (1985). https://doi.org/10.1007/BF02469749

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  • DOI: https://doi.org/10.1007/BF02469749

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