Abstract
A 12-year-old Japanese boy noticed a red nodule on the distal portion of his right great toe about 2 months before entering our clinic. There was evidence of traumatic injury and infection before the appearance of the nodule. Histological examination showed the subcutaneous localization of bony spicules lined by osteoblasts. Haversian canals, which contained blood vessels and connective tissue, were also seen. Electron microscopic examination revealed normal bone structure, but, interestingly, mesenchymal cells that were localized around the tumor had intranuclear inclusions composed of filamentous bundles. From these findings, this case was diagnosed as subungual exostosis. It is suggested that the appearance of intranuclear inclusions, reported here for the first time, is related to the pathogenesis of subungual exostosis.
Similar content being viewed by others
References
Iizuka T, Kinoshita Y, Fukumoto K (1995) Subungual exostosis of the finger. Ann Plastic Surg 35:330–332
Muse G, Rayan G (1986) Subungual exostosis. Orthopedics 9:997–998
Woo TY, Rasmussen JE (1985) Subungual osteocartilaginous exostosis. J Dermatol Surg Oncol 11:534–536
Bendl BJ (1980) Subungual exostosis. Cutis 26:260–262
Miller-Breslow A, Dorfman HD (1988) Dupuytren's (subungual) exostosis. Am J Surg Pathol 12:368–378
Kato H, Nakagawa K, Tsuji T, Hmada T (1990) Subungual exostoses-clinicopathological and ultrastructural studies of three cases. Clin Exp Dermatol 15:429–431
Hoover KL, Harshbarger JC, Lee CW, Banfield W, Chang SC (1981) Intranuclear inclusion bodies within neurons of spinal and cranial ganglia in three cyprinid species. Cell Tissue Res 218:529–536
Lafarga M, Palacios G (1979) Nuclear inclusions in paraventricular nucleus neurons of the rat hypothalamus. Cell Tissue Res 203:223–229
Booss J, Winkler SR, Griffith SP, Kim JH (1989) Viremia and glial nodule encephalitis after experimental systemic cytomegalovirus infection. Lab Invest 61:644–649
Ito M, Hirabayashi N, Uno Y, Nakayama A, Asai J (1991) Necrotizing tubulointerstitial nephritis associated with adenovirus infection. Hum Pathol 22:1225–1231
Tsumuraya M, Kodama T, Kameya T, Shimosato T, Koketsu H, Uei Y (1981) Light and electron microscopic analysis of intranuclear inclusions in papillary adenocarcinoma of the lung. Acta Cytol 25:523–532
Hashimoto K, Kumakiri M (1976) Intranuclear tonofilaments in verruca vulgaris. J Invest Dermatol 67:285–287
Davies MG, Barton SP, Stai F, Marks R (1980) The abnormal dermis in pyogenic granuloma. Histochemical and ultrastructural observations. J Am Acad Dermatol 2:132–142
Shelton KR, Egle PM (1982) The proteins of lead-induced intranuclear inclusion bodies. J Biol Chem 257:11802–11807
Glimcher MJ, Krane SM (1968) Organization and structure of bone and mechanism of calcification. In: Ramachandran G, Gould BS (eds) Treatise on collagen. Academic Press, London, pp 68–251
Boivin G, Walzer C, Baud CA (1987) Ultrastructural study of the long-term development and of two experimental cutaneous calcinosis (topical calciphylaxis and topical calcergy) in rat. Cell Tissue Res 247:525–532
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kagoura, M., Toyoda, M. & Morohashi, M. An ultrastructural study of subungual exostosis, with special reference to intranuclear inclusions. Med Electron Microsc 31, 142–146 (1998). https://doi.org/10.1007/BF01553782
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01553782