Abstract
The DnaJ protein family consists of proteins with a highly conserved amino acid stretch called the "J - domain". A cDNA clone encoding a new protein with a J-domain was isolated from a human fetal brain cDNA library. This new member of the DnaJ family of 241 amino acid residues showed 94% identity with mouse Mrj (accession number, AF035962) and 71% identity with mouse Msj-1 (accession number, U95607) along its entire sequence. Reverse transcription - coupled polymerase chain reaction (RT-PCR) analysis showed the messenger RNA was ubiquitously expressed in various human tissues. The chromosomal location of the gene was determined by PCR-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel to map on chromosome 11q25 region.
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Received: November 16, 1998 / Accepted: January 22, 1999
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Seki, N., Hattori, A., Hayashi, A. et al. Cloning, tissue expression, and chromosomal assignment of human MRJ gene for a member of the DNAJ protein family. J Hum Genet 44, 185–189 (1999). https://doi.org/10.1007/s100380050139
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DOI: https://doi.org/10.1007/s100380050139
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