Abstract
Background. Lymph node metastasis has been recognized as the most reliable prognostic factor for colorectal cancer. Of late, the clinical significance of p53 as a prognostic factor has been reported. The purpose of the current study was to elucidate the significance of these two factors in combination as a prognostic indicator for colorectal cancer.
Methods. One hundred forty-four patients with colorectal cancer were examined. The expression of p53 was determined by immunohistochemical staining. Patient data, lymph node metastasis, p53 expression, recurrence rate, 5-year survival, and disease-free survival were studied.
Results. The recurrence rate for patients with p53− and n1 in combination was 21%, and that for patients with p53+ and n1 in combination was 63%, a significant difference. The 5-year survival rate for patients with p53− and n1 in combination was not significantly different from that for patients with p53+ and n1 in combination (78.7% vs. 57.5%); however, the 5-year disease-free survival rate for patients with p53− and n1 in combination was significantly better than that for patients with p53+ and n1 in combination (78.6% vs. 38.2%).
Conclusion. The combination criterion of lymph node metastasis and p53 expression should be a useful prognosticator for colorectal cancer.
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Received: September 11, 1998 / Accepted: May 18, 1999
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Yamamura, T., Matsuzaki, H., Suda, T. et al. Lymph node metastasis and p53 overexpression in combination for the prognosis for the colorectal cancer. Int J Clin Oncol 4, 280–284 (1999). https://doi.org/10.1007/s101470050068
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DOI: https://doi.org/10.1007/s101470050068