Abstract
Background
Whereas the creatinine generation rate may reflect only the protein nutritional status by way of muscle mass, the predialysis serum albumin concentration may well reflect a variety of aspects of a patient's pathophysiologic status, including the protein nutritional status. The aim of this study was to clarify whether or not serum albumin concentration and the creatinine generation rate reflect the same pathophysiologic status.
Methods
The risk of death associated with the creatinine generation rate was studied with and without adjustment for the serum albumin concentration in 1588 patients undergoing hemodialysis. A comparison was also made between the death risk associated with serum albumin concentrations with and without adjustment for the creatinine generation rate. Possible correlations between the creatinine generation rate and serum albumin concentration were evaluated.
Results
The death risk associated with the creatinine generation rate was little changed when adjusted for serum albumin concentration. However, the death risk associated with serum albumin concentration remained high even after being adjusted by the creatinine generation rate. Moreover, the correlation was very weak between the creatinine generation rate and the serum albumin concentration.
Conclusions
Serum albumin concentration and the creatinine generation rate do not reflect the same pathophysiologic status.
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Nakai, S., Shinzato, T., Miwa, M. et al. Predialysis serum albumin concentration and creatinine generation rate do not reflect the same pathophysiologic status. Clin Exper Neph 2, 44–49 (1998). https://doi.org/10.1007/BF02480623
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DOI: https://doi.org/10.1007/BF02480623