Summary.
Recently a mutation in the parkin gene has been identified as the cause for an autosomal-recessively inherited form of early onset Parkinson's disease (EOPD). The disease causing minimal deletion has been defined as a homozygous exon 4 loss in the parkin gene among Japanese patients. We investigated 140 sporadic and familial EOPD patients of German ancestry for the exon 4 deletion in the parkin gene. None of our patients exhibited a homo-zygous deletion of exon 4, suggesting a minor role of this mutation for EOPD in Caucasians. Nevertheless a detailed mutation analysis is warranted to explore the overall significance of mutations in the parkin gene in EOPD.
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Received September 18, 1998; accepted November 26, 1998
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Krüger, R., Vieira-Säcker, A., Kuhn, W. et al. Analysis of the parkin deletion in sporadic and familial Parkinson's disease. J Neural Transm 106, 159–163 (1999). https://doi.org/10.1007/s007020050148
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DOI: https://doi.org/10.1007/s007020050148