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Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat

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Summary

Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.

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Abbreviations

DA :

dopamine

DOPAC :

3,4-dihydroxyphenylacetic acid

HVA :

homovanillic acid

DOPA :

3,4-dihydroxyphenylalanine

NA :

noradrenaline

MHPG :

3-methoxy-4-hydroxyphenylgly-col

NMN :

normetanephrine

TRP :

tryptophan

5-HTP :

5-hydroxytryptophan

5-HT :

serotonin

5-HIAA :

5-hydroxy-3-indolacetic acid

TH :

tyrosine hydroxylase

TPH :

tryptophan hydroxylase

MAO-A :

monoamine oxidase-A

MAO-B :

monoamine oxidase-B

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Author notes

  1. J. Cano

    Present address: Departamento de Bioquímica, Bromatología y Toxicologia, Universidad de Sevilla, Spain

Authors and Affiliations

  1. Departamento de Bioquímica, Bromatología y Toxicologia, Universidad de Sevilla, Spain

    M. L. Vizuete, M. Santiago, A. J. Herrera, J. L. Venero & A. Machado

Authors
  1. M. L. Vizuete
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  2. M. Santiago
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  3. A. J. Herrera
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  4. J. L. Venero
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  5. A. Machado
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  6. J. Cano
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Additional information

Recipients of fellowships from I.I.E. del FISS Reincorporación de doctores y tecnólogos del M.E.C., and Perfeccionamiento de doctores y tecnólogos del MEC, Spain

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Vizuete, M.L., Santiago, M., Herrera, A.J. et al. Effects of neonatal bilateral eye enucleation on postnatal development of the monoamines in posterior thalamus of the rat. J. Neural Transmission 85, 231–242 (1991). https://doi.org/10.1007/BF01244948

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  • DOI: https://doi.org/10.1007/BF01244948

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