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Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides

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Summary

Only one peptide of CD4 (amino acid residues 70–132) among 16 synthetic peptide fragments selectively inhibited HIV-1 replication and HIV-1-induced syncytium formation. Several smaller peptides within this region did not show any activity, except for the peptide (86–132) which showed somewhat lower activity.

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Authors and Affiliations

  1. Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka

    Yoshio Hayashi, Kazuyoshi Ikuta & Shiro Kato

  2. Laboratory of Biochemistry, The Calpis Food Industry Co., Ltd., Sagamihara, Kanagawa

    Yoshio Hayashi & Kunio Ezawa

  3. Faculty of Pharmaceutical Science, Kyoto University, Sakyo-ku, Kyoto, Japan

    Nobutaka Fujii

Authors
  1. Yoshio Hayashi
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  2. Kazuyoshi Ikuta
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  3. Nobutaka Fujii
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  4. Kunio Ezawa
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  5. Shiro Kato
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Hayashi, Y., Ikuta, K., Fujii, N. et al. Inhibition of HIV-1 replication and syncytium formation by synthetic CD4 peptides. Archives of Virology 105, 129–135 (1989). https://doi.org/10.1007/BF01311123

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  • DOI: https://doi.org/10.1007/BF01311123

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